Anti-Human EGFR Recombinant Antibody (TAB-040) (CAT#: TAB-040)
Recombinant monoclonal antibody to EGFR. It is a fully human IgG1 monoclonal antibody (mAb) directed towards the epidermal growth factor receptor (EGFr). the Netherlands. Specifically, it is designed for the treatment of squamous cell carcinoma of the head and neck (SCCHN), a type of cancer. The current treatment for SCCHN includes tyrosine kinase inhibitors and human monoclonal antibodiess. In addition, murine mAbs were tested successfully in mice, but caused an immune response in humans and were thus determined as ineffective in therapeutics.
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ELISA
Figure 1 Anti-Human EGFR Antibody (TAB-040) in ELISA
ELISA analysis of TAB-040 was performed with EGFR Protein, Human, Recombinant (His Tag).
The secondary antibody: HRP-Anti-Human IgG (H+L)
WB
Figure 2 Anti-Human EGFR Antibody (TAB-040) in WB
Western blot analysis of TAB-040 was performed with EGFR Protein, Human, Recombinant (His Tag).
TAB-040 incubation concentration: 2ng/μL.
The secondary antibody: HRP-Anti-Human IgG (H+L)
Lane 1: Reducing antigen (0.6μg)
DB
Figure 3 Anti-Human EGFR Antibody (TAB-040) in DB
Dot blot analysis of TAB-040 was performed with EGFR Protein, Human, Recombinant (His Tag).
TAB-040 incubation concentration: 2ng/μL.
NC: Negative control PC: Positive control
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut, ICC
- MW
- 148 kDa
- Related Disease
- Head and neck cancers
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The EGFR antibody has been reported in applications of FC, ADCC, Inhib, IHC.
Target
- Alternative Names
- Zalutumumab;humax-egfr;667901-13-5;HuMax-EGFR;2F8;EGFR;epidermal growth factor receptor;epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB;ERBB1;erythroblastic leukemia viral (v erb b) oncogene homolog
- Gene ID
- 1956
- UniProt ID
- P00533
Related Resources
Please refer to Zalutumumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Zalutumumab.
Bladder Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Hepatocellular Carcinoma
Cushing Syndrome
JAK-STAT Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Chimeric Antibodies
Humanized Antibodies
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FC Reagents & Kits
IHC Kits & Antibodies
Extracellular Vesicle Antibodies
Biparatopic Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H35 | Anti-Human EGFR Recombinant Antibody (Futuximab) | IF, WB, Inhib | IgG1 - kappa |
| TAB-0225CL | Human Anti-EGFR Recombinant Antibody (TAB-0225CL) | Block, Inhib, FuncS, Apop, In vivo | Chimeric (Mouse/Human) IgG1 |
| TAB-0225CL-F(E) | Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-0225CL-F(E)) | Block, Inhib, FuncS, Apop, In vivo | Chimeric (Mouse/Human) Fab |
| TAB-272MZ | Human Anti-EGFR Recombinant Antibody (TAB-272MZ) | FuncS | Chimeric (mouse/human) IgG |
| TAB-464CQ | Anti-Human EGFR Recombinant Antibody (TAB-464CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
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