Human Anti-EGFR Recombinant Antibody (clone h-R3) (CAT#: PABL-463)

Recombinant Humanized Antibody (h-R3) is capable of binding to EGFR, expressed in Chinese Hamster Ovary cells (CHO).

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Figure 1 Immunohistochemistry analysis of expression of selected markers (Ki67 and FVIII) in tumor biopsies of a patient treated with h-R3 and radiotherapy before and on-week 3 (on–therapy).

Figure 1 Immunohistochemistry analysis of expression of selected markers (Ki67 and FVIII) in tumor biopsies of a patient treated with h-R3 and radiotherapy before and on-week 3 (on–therapy).

EGFR expression was classified as 3 in all patients. Before treatment, Ki67 staining ranged from 42% to 65% (median, 57%). Proliferative activity decreased at week 3; Ki67 staining ranged from 0% to 29% (median, 16%).

Crombet, T., Osorio, M., Cruz, T., Roca, C., del Castillo, R., Mon, R., ... & Fernández, E. (2004). Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients. Journal of Clinical Oncology, 22(9), 1646-1654.


Specifications

  • Immunogen
  • Human epidermal growth factor receptor
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized IgG
  • Specificity
  • Human EGFR
  • Species Reactivity
  • Human
  • Clone
  • h-R3
  • Applications
  • ELISA, WB, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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