Human Anti-ENG Recombinant Antibody (clone Vκ2VH1); Fab Fragment

Name: Human Anti-ENG Recombinant Antibody (clone Vκ2VH1); Fab Fragment
SKU: HPAB-0231-YC-F(E)
Rating: 5 (1 reviews)

CAT#: HPAB-0231-YC-F(E)

The antibody is a recombinant monoclonal antibody Fab fragment against Endoglin (ENG). Endoglin, also known as, inter alia, CD105 or edg-1, is a type I homodimeric membrane glycoprotein which is expressed at high levels in proliferating vascular endothelial cells. Thus, endoglin is primarily a proliferation-associated marker for endothelial cells undergoing active angiogenesis. However, there is some expression of endoglin by the vascular endothelium of normal tissues.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1823_F9_38_selected.jpg

Subcellular Location Figure 2 IHC staining of human placenta

Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11862/158146_A_2_7_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1777_G1_13_cr59632eeaa8e82_blue_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1759_C2_13_cr594b6f97edc10_blue_red_green.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/156475_A_9_5.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG

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Specifications

Host Species
Human

Derivation
Humanized

Type
Humanized Fab

Specificity
Human ENG

Species Reactivity
Human, Mouse, Monkey

Clone
Vκ2VH1

Applications
ELISA, WB, FuncS

Related Disease
Endoglin-associated disease

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Endoglin; CD105 Antigen; END; Osler-Rendu-Weber Syndrome 1; HHT1; ORW1

Gene ID
2022

UniProt ID
P17813

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0231-YC-F(E).pdf

MSDS

MSDS - HPAB-0231-YC-F(E).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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