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    Anti-Human EPCAM Recombinant Antibody (h12H8C) (CAT#: TAB-375MZ)

    This antibody h12H8C specifically binds to epithelial cell adhesion/activating molecule EpCAM expressed on cancer cells, which can induce cancer cell apoptosis. The antibody can be potentially used as diagnostic and therapeutic agents.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    FuncS

    Figure 1 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in pancreatic cancer cell in the presence of human PBMC.

    Figure 1 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in pancreatic cancer cell in the presence of human PBMC.

    Inhib

    Figure 2 shows effect of bsAbs on % of cell growth inhibition in pancreatic cancer cell in the presence of hPBMC.

    Figure 2 shows effect of bsAbs on % of cell growth inhibition in pancreatic cancer cell in the presence of hPBMC.

    FuncS

    Figure 3 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in Multiple Myeloma cell RPMI 8266 in the presence of human PBMC.

    Figure 3 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in Multiple Myeloma cell RPMI 8266 in the presence of human PBMC.

    Inhib

    Figure 4 shows effect of bsAbs on % of cell growth inhibition in lung cancer cell NCI-H358 in the presence of hPBMC.

    Figure 4 shows effect of bsAbs on % of cell growth inhibition in lung cancer cell NCI-H358 in the presence of hPBMC.

    FuncS

    Figure 5 shows antitumor activity of hl2H8CXanti-CD3 (hl2H8C-v2.1 and hl2H8C-v2.1-sHSA) in human DLD-1 colon carcinoma xenograft model (Mean+SEM) (* p<0.05 as compared to PBS control group).

    Figure 5 shows antitumor activity of hl2H8CXanti-CD3 (hl2H8C-v2.1 and hl2H8C-v2.1-sHSA) in human DLD-1 colon carcinoma xenograft model (Mean+SEM) (* p<0.05 as compared to PBS control group).


    Specifications

    • Host Species
    • Human
    • Type
    • Humanized antibody
    • Specificity
    • Human
    • Clone
    • h12H8C
    • Applications
    • FuncS, Inhib
    • Related Disease
    • Cancers such as breast cancer, colorectal cancer, gastric cancer, lung cancer, and prostate cancer

    Applications

    • Application Notes
    • This antibody has been reported for use in Functional Assay, Inhibition.

    Target

    • Alternative Names
    • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    CAT Product Name Application Type
    TAB-106 Anti-Human EPCAM Recombinant Antibody (Adecatumumab) FC, IHC, FuncS, Inhib, Cyt IgG1
    TAB-356MZ Anti-Human EPCAM Recombinant Antibody (3-171) Cyt, ELISA, FC, WB Human antibody
    TAB-357MZ Anti-Human EPCAM Recombinant Antibody (7-F17) ELISA Human antibody
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    TAB-359MZ Anti-Human EPCAM Recombinant Antibody (16-G5) ELISA Human antibody

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