Anti-Human EPCAM Recombinant Antibody (h12H8C) (CAT#: TAB-375MZ)
This antibody h12H8C specifically binds to epithelial cell adhesion/activating molecule EpCAM expressed on cancer cells, which can induce cancer cell apoptosis. The antibody can be potentially used as diagnostic and therapeutic agents.
Specific Inquiry
FuncS
Figure 1 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in pancreatic cancer cell in the presence of human PBMC.
Inhib
Figure 2 shows effect of bsAbs on % of cell growth inhibition in pancreatic cancer cell in the presence of hPBMC.
FuncS
Figure 3 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in Multiple Myeloma cell RPMI 8266 in the presence of human PBMC.
Inhib
Figure 4 shows effect of bsAbs on % of cell growth inhibition in lung cancer cell NCI-H358 in the presence of hPBMC.
FuncS
Figure 5 shows antitumor activity of hl2H8CXanti-CD3 (hl2H8C-v2.1 and hl2H8C-v2.1-sHSA) in human DLD-1 colon carcinoma xenograft model (Mean+SEM) (* p<0.05 as compared to PBS control group).
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- h12H8C
- Applications
- FuncS, Inhib
- Related Disease
- Cancers such as breast cancer, colorectal cancer, gastric cancer, lung cancer, and prostate cancer
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Inhibition.
Target
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)
- Gene ID
- 4072
- UniProt ID
- P16422
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-112-F(E) | Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Fab - G1 - kappa |
| TAB-235CL | Human Anti-Human EPCAM Recombinant Antibody (3622W94) | Cyt, FC | Antibody |
| TAB-374MZ | Anti-Human EPCAM Recombinant Antibody (h12H8B) | FC, ELISA | Humanized antibody |
| TAB-376MZ | Anti-Human EPCAM Recombinant Antibody (h2D11B) | Cyt, Inhib | Humanized antibody |
| TAB-362MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (3622W94) | Confocal, ELISA | Humanized antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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