This antibody h12H8C specifically binds to epithelial cell adhesion/activating molecule EpCAM expressed on cancer cells, which can induce cancer cell apoptosis. The antibody can be potentially used as diagnostic and therapeutic agents.
Figure 1 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in pancreatic cancer cell in the presence of human PBMC.
Figure 2 shows effect of bsAbs on % of cell growth inhibition in pancreatic cancer cell in the presence of hPBMC.
Figure 3 shows effect of AbGn bsAbs on cytotoxic activity (% of cell death) in Multiple Myeloma cell RPMI 8266 in the presence of human PBMC.
Figure 4 shows effect of bsAbs on % of cell growth inhibition in lung cancer cell NCI-H358 in the presence of hPBMC.
Figure 5 shows antitumor activity of hl2H8CXanti-CD3 (hl2H8C-v2.1 and hl2H8C-v2.1-sHSA) in human DLD-1 colon carcinoma xenograft model (Mean+SEM) (* p<0.05 as compared to PBS control group).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-701 | Anti-Human EpCAM/17-1A Recombinant Antibody (Edrecolomab) | ELISA, IP, FC, FuncS, IF, Neut | IgG2a - kappa |
TAB-363MZ-F(E) | Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-363MZ-F(E)) | Confocal, ELISA | Mouse Fab |
TAB-364MZ-F(E) | Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-364MZ-F(E)) | NIR (Near-infrared) fluorescence imaging, ELISA | Mouse Fab |
TAB-365MZ-F(E) | Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-365MZ-F(E)) | NIR (Near-infrared) fluorescence imaging, ELISA | Mouse Fab |
TAB-366MZ-F(E) | Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-366MZ-F(E)) | ELISA, WB, IHC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-106 | Anti-Human EPCAM Recombinant Antibody (Adecatumumab) | FC, IHC, FuncS, Inhib, Cyt | IgG1 |
TAB-356MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (3-171) | FC, ELISA | Human antibody |
TAB-357MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (7-F17) | FC, ELISA | Human antibody |
TAB-358MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (12-C15) | FC, ELISA | Human antibody |
TAB-359MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (16-G5) | FC, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-112-F(E) | Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Fab - G1 - kappa |
TAB-362MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (3622W94) | Confocal, ELISA | Humanized antibody |
TAB-374MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (h12H8B) | FC, ELISA | Humanized antibody |
TAB-375MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (h12H8C) | FC, ELISA | Humanized antibody |
TAB-376MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (h2D11B) | FC, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L013E | anti-EPCAM immunotoxin MOC31 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L013D | anti-EPCAM immunotoxin MOC31 (IgG)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L013G | anti-EPCAM immunotoxin MOC31 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L013R | anti-EPCAM immunotoxin MOC31 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L013O | anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1163 | Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) | IHC-P, WB, ICC, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0095-YC-S(P) | Mouse Anti-EPCAM Recombinant Antibody (clone MOC31); scFv Fragment | ELISA | Mouse scFv |
HPAB-0163CQ-S(P) | Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54); scFv Fragment | ELISA, FC, FuncS | Human scFv |
HPAB-AP077-YC-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-AP077-YC-S(P)) | FC, IP | Mouse scFv |
HPAB-S0026-YC-S(P) | Human Anti-EPCAM Recombinant Antibody (clone H79); scFv Fragment | ELISA, FC, Cyt | Human scFv |
HPAB-2051-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone 02-237); scFv Fragment | FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0163CQ | Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54) | ELISA, FC, FuncS | Human IgG1 |
HPAB-2216LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2216LY) | ELISA | Human IgG |
HPAB-2217LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2217LY) | ELISA | Human IgG |
HPAB-2218LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2218LY) | ELISA | Human IgG |
HPAB-2219LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2219LY) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-106 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-213 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS | ADCC enhanced antibody |
AFC-TAB-701 | Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2216LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) | ELISA | Human Fab |
HPAB-2217LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) | ELISA | Human Fab |
HPAB-2218LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) | ELISA | Human Fab |
HPAB-2219LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) | ELISA | Human Fab |
HPAB-2220LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2220LY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0031 | APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM | |
MHC-CN0032 | PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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