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Anti-ERBB2 immunotoxin FRP5 (IgG)-RTA (AGTO-G023R)

This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to ovarian cancer cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of ovarian Cancer .      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
FRP5
Molecule Class
IgG-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Ovarian Cancer
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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PE-B*07:02/Human ERBB2 (MPNQAQMRI) MHC Tetramer    ( MHC-LC2523 )
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PE-A*24:02/Human ERBB2 (AYSLTLQGL) MHC Tetramer    ( MHC-LC3033 )
A*02:01/Human Her-2/neu E75 (KIFGSLAFL) MHC Tetramer    ( MHC-LC006 )
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