Creative Biolabs Recombinant Antibodies
Products
  1. Home
  2. ERBB2
  3. Anti-ERBB2 immunotoxin FRP5 (IgG)-RTA

Anti-ERBB2 immunotoxin FRP5 (IgG)-RTA (AGTO-G023R)

This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to ovarian cancer cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of ovarian Cancer .      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
FRP5
Molecule Class
IgG-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Ovarian Cancer
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "ERBB2"
Recombinant Chimeric Anti-ERBB2 (extracellular domain) Antibody scFv Fragment (chA21)    ( PSBL-464 )
PE-A*02:01/Human ERBB2 (LLGICLTSTV) MHC Tetramer    ( MHC-LC2772 )
PE-A*02:06/Human ERBB2 (HLYQGCQVV) MHC Tetramer    ( MHC-LC3077 )
PE-A*01:01/Human ERBB2 (ETLEEITGY) MHC Tetramer    ( MHC-LC2633 )
Recombinant Human Anti-ERBB2 Antibody Fab Fragment (bH1)    ( PFBZ-041 )
Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel    ( AGTO-G022G )
Anti-HER2-DBCO-MMAF ADC    ( ADC-308CL )
Anti-HER2-MT-vc-MMAE ADC    ( ADC-254CL )
>> MORE
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Increase Efficiency to Accelerate Your Research & Discovery Process

Increase Efficiency to Accelerate Your Research & Discovery Process

Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production ...

Find out more >

USA

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356

Europe

Tel: 44-207-097-1828
Email:
Follow us on:
           

Terms of Service-Privacy Policy     © 2007 - 2019 Creative-Biolabs All Rights Reserved