Anti-Human ERBB2 Recombinant Antibody (TAB-H70)

Name: Anti-Human ERBB2 Recombinant Antibody (TAB-H70)
SKU: TAB-H70
Rating: 5 (1 reviews)

CAT#: TAB-H70

Recombinant Humanized (from mouse) antibody to Human ERBB2. It is an antibody-drug conjugate consisting of the monoclonal antibody linked to the cytotoxic agent mertansine (DM1). Trastuzumab alone stops growth of cancer cells by binding to the HER2/neu receptor, whereas mertansine enters cells and destroys them by binding to tubulin. Because the monoclonal antibody targets HER2, and HER2 is only over-expressed in cancer cells, the conjugate delivers the toxin specifically to tumor cells. The conjugate is abbreviated T-DM1.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg

Normal Tissue Figure 3 High expression in esophagus

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg

Normal Tissue Figure 4 IHC staining of human rectum

Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg

Normal Tissue Figure 5 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg

Normal Tissue Figure 6 Kidney

Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg

Normal Tissue Figure 7 Breast

Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

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Specifications

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1 - kappa

Specificity
ERBB2(epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340) [Homo sapiens]

Species Reactivity
Human

Applications
ELISA, IP, FC, FuncS, Neut, IF, ICC

MW
148.5 kDa

Related Disease
Breast cancers overexpressing ERBB2, metastatic

Product Property

Purity
>95.0% as determined by analysis by RP-HPLC.

Applications

Application Notes
The ERBB2 antibody has been reported in applications of WB, FC.

Target

Alternative Names
trastuzumab emtansine;trastuzumab emtansine;1018448-65-1;PRO132365;trastuzumab-MCC-DM1;Trastuzumab-DM1;T-DM1;RG3502;trastuzumab emtansine;ado-trastuzumab emtansine;ERBB2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian);NG

Gene ID
2064

UniProt ID
P04626

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(Creative Biolabs Cat# TAB-H70, RRID: AB_3112043)

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Related Diseases

Bladder Cancer

Non-small Cell Lung Cancer

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-H70.pdf

MSDS

MSDS - TAB-H70.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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IAB-B008(A)	Recombinant Anti-human ERBB2 Intrabody [(D-Arg)₉]	IF, FC, FuncS	scFv-(D-Arg)₉
IAB-B008(G)	Recombinant Anti-human ERBB2 Intrabody [+36 GFP]	WB, ICC, FuncS	scFv-(+36GFP)
IAB-B008(T)	Recombinant Anti-human ERBB2 Intrabody [Tat]	ICC, Neut, FuncS	scFv-Tat

CAT	Product Name	Application	Type
TAB-761	Anti-ERBB2 Recombinant Antibody (Margetuximab)	IF, IP, Neut, FuncS, ELISA, FC, WB	IgG1 - kappa
TAB-049CT	Anti-Human HER2/neu Recombinant Antibody (ChA21)	IHC, Inhib, WB, Activ, FC	Chimeric antibody (mouse/human)
TAB-049CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21)	WB	Chimeric antibody (mouse/human)
TAB-049CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21)	WB	Chimeric antibody (mouse/human)

CAT	Product Name	Application
AGTO-G022E	Anti-ERBB2 immunotoxin 4D5 (scFv)-PE	Cytotoxicity assay, Function study
AGTO-G022D	Anti-ERBB2 immunotoxin 4D5 (scFv)-DT	Cytotoxicity assay, Function study
AGTO-G022G	Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel	Cytotoxicity assay, Function study
AGTO-G022R	Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA	Cytotoxicity assay, Function study
AGTO-G022S	Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap	Cytotoxicity assay, Function study

CAT	Product Name	Application	Type
PNBL-066	Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-066)	SPR	Llama VHH
HPAB-0201-FY	Recombinant llama Anti-ERBB2 Antibody (HPAB-0201-FY)	E	llama VHH
HPAB-0202-FY	Recombinant llama Anti-ERBB2 Antibody (HPAB-0202-FY)	E	llama VHH
HPAB-0203-FY	Recombinant llama Anti-ERBB2 Antibody	IF	llama VHH
HPAB-0725-YJ-VHH	Camelid Anti-ERBB2 Recombinant Single Domain Antibody (HPAB-0725-YJ-VHH)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
PABW-161	Mouse Anti-ERBB2 Recombinant Antibody (clone chA21)	FC, WB	Mouse IgG
PABC-157	Human Anti-ERBB2 Recombinant Antibody (clone F0178C1)	Neut	Human IgG
MOB-014LC	Mouse Anti-ERBB2 Recombinant Antibody (MOB-014LC)	ELISA, FC	Mouse IgG
MOB-014LC-F(E)	Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (MOB-014LC-F(E))	ELISA, FC	Mouse Fab
MOB-014LC-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (MOB-014LC-S(P))	ELISA, FC	Mouse scFv

CAT	Product Name	Application	Type
PFBL-463	Human Anti-ERBB2 Recombinant Antibody Fab Fragment (PFBL-463)	WB	Human Fab
HPAB-0733LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone AH06); Fab Fragment	ELISA	Human Fab
HPAB-0734LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone A058); Fab Fragment	ELISA	Human Fab
HPAB-0735LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone AH16); Fab Fragment	ELISA	Human Fab
HPAB-0736LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone A091); Fab Fragment	ELISA	Human Fab

CAT	Product Name	Application	Type
PSBZ-041	Human Anti-ERBB2 Recombinant Antibody (clone bH1); scFv Fragment	WB, IF, FuncS	Human scFv
HPAB-0091-FY-S(P)	Human Anti-ERBB2 Recombinant Antibody (clone MIL12); scFv Fragment	ELISA	Humanized scFv
HPAB-1111LY-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1111LY-S(P))	ELISA	Mouse scFv
HPAB-1112LY-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1112LY-S(P))	ELISA	Human scFv
HPAB-0193-WJ-S(P)	Mouse Anti-ERBB2 Recombinant Antibody (clone 6H8); scFv Fragment	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-0191CL-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0191CL-S(P))	ELISA, Cyt, Internalization	Human scFv
TAB-0192CL-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0192CL-S(P))	ELISA, Cyt, Internalization	Human scFv
TAB-0193CL-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0193CL-S(P))	ELISA, Cyt, Internalization	Human scFv
TAB-0194CL-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-0194CL-S(P))	ELISA, Cyt, Internalization	Human scFv
PABX-081-S (P)	Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr3)	WB, ELISA, FuncS	scFv

CAT	Product Name	Application	Type
TAB-034CT	Anti-Human HER2/neu Recombinant Antibody (TAB-034CT)	WB
TAB-036CT	Anti-Human HER2/neu Recombinant Antibody (6B2)	ELISA, WB
TAB-037CT	Anti-Human HER2/neu Recombinant Antibody (7C2/7F3)	ELISA, WB
TAB-034CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (TAB-034CT-F(E))	WB
PABX-082-S (P)	Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr6)	WB, ELISA, FuncS	scFv

CAT	Product Name	Application	Type
TAB-033CT-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-033CT-F(E))	ELISA, WB	Humanized Fab
TAB-038CT-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-038CT-F(E))	WB	Humanized Fab
TAB-039CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (h1E11)	WB	Humanized antibody
TAB-041CT-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-041CT-F(E))	ELISA, WB	Humanized Fab
TAB-050CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (HuA21)	ELISA, WB	Humanized antibody

CAT	Product Name	Application	Type
Gly-024LC	Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)	ELISA	Mouse antibody

CAT	Product Name	Application	Type
Gly-117LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Humanized antibody
Gly-145LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-146LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-147LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-148LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-177LC	Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
BRD-0195MZ	Chicken Anti-ERBB2 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-737CQ	Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4)	Block, IP, IF, FC	Mouse IgG2a

CAT	Product Name	Application	Type
MOR-1178	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB)	IHC-P, IHC-Fr	Rabbit IgG
MOR-4586	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS)	WB	Rabbit IgG
MOR-4587	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS)	WB	Rabbit IgG

CAT	Product Name	Application
MHC-LC3080	APC-A*02:02/Human ERBB2 (ILHNGAYSL) MHC Tetramer	FCM
MHC-LC3081	APC-A*02:03/Human ERBB2 (ILHNGAYSL) MHC Tetramer	FCM
MHC-LC3082	APC-A*02:06/Human ERBB2 (ILHNGAYSL) MHC Tetramer	FCM
MHC-YF221	A*02:01/Human Her-2/neu (KIFGSLAFL) MHC Monomer	MHC Multimer
MHC-YF222	A*02:01/Human Her-2/neu (RLLQETELV) MHC Monomer	MHC Multimer

CAT	Product Name	Application	Type
AFC-TAB-468CQ	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-468CQ)	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-053	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-053)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-761	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-761)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-005	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY91	AbPlus™ Anti-ERBB2 Magnetic Beads (3.F2)	IP, Protein Purification
VS-0724-YC1516	AbPlus™ Anti-Erbb2 Magnetic Beads (VS-0724-YC1516)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY24	Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera	FC, BI	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY108	CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC430	Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY2335	Anti-ERBB2 Immunohistochemistry Kit	IHC
VS-0525-XY2336	Anti-Mouse ERBB2 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC3	Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab	ELISA	Symmetric scFv-Fab
VS-0525-YC6	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero Fab	ELISA	Asymmetric hetero Fab
VS-0525-YC7	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero HC-LC	ELISA, Inhib	Asymmetric hetero HC, common LC

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