Anti-Human ERBB3 Recombinant Antibody (Lumretuzumab) (CAT#: TAB-H47)
This product is a recombinant humanized antibody that recognizes human ERBB3.
Specific Inquiry
ELISA
Figure 1 Mean ( SD) serum lumretuzumab profiles following single ascending doses from 100 mg up to 2,000 mg for cycle 1.
Meulendijks, D., Jacob, W., Martinez-Garcia, M., Taus, A., Lolkema, M. P., Voest, E. E., ... & Sleijfer, S. (2016). First-in-human phase I study of lumretuzumab, a glycoengineered humanized anti-HER3 monoclonal antibody, in patients with metastatic or advanced HER3-positive solid tumors. Clinical Cancer Research, 22(4), 877-885.
Inhib
Figure 2 HER3 expression in a liver lesion biopsy from a patient with colon cancer sampled prior and 14 days after treatment with 400 mg lumretuzumab.
The images show intense staining of tumor cell membranes and low cytoplasmic staining in the pre-treatment biopsy with loss of membrane staining.
Meulendijks, D., Jacob, W., Martinez-Garcia, M., Taus, A., Lolkema, M. P., Voest, E. E., ... & Sleijfer, S. (2016). First-in-human phase I study of lumretuzumab, a glycoengineered humanized anti-HER3 monoclonal antibody, in patients with metastatic or advanced HER3-positive solid tumors. Clinical Cancer Research, 22(4), 877-885.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG1, κ
- Specificity
- Human ERBB3
- Species Reactivity
- Human
- Clone
- Lumretuzumab
- Applications
- ELISA, Inhib
- Conjugate
- Unconjugated; Biotin; Alexa Fluor 350; Alexa Fluor 405; Alexa Fluor 488; Alexa Fluor 532; Alexa Fluor 594; Alexa Fluor 647; Alexa Fluor 700; Alexa Fluor 750; Biotin; DyLight 350; DyLight 405; DyLight 488; DyLight 550; DyLight 594; DyLight 650; DyLight 680; DyLight 755; FITC; HRP
- Related Disease
- Tumor
Product Property
- Purification
- Protein A/G purified
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Applications
- Application Notes
- The Human ERBB3 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Inhibition.
Target
- Alternative Names
- HER3; FERLK; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; human epidermal growth factor receptor 3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
Please refer to Lumretuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lumretuzumab.
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single-domain Antibody
Recombinant Antibody
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Human Antibody
Neutralizing Antibody
Rabbit Monoclonal Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
Customer Reviews and Q&As
Customer Review
Q&As
-
Ideal for ERBB3 Studies
The Anti-ERBB3 Antibody (Lumretuzumab) has been excellent for our ERBB3 research. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time. -
Effective in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for ERBB3 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab. -
Consistent and Reliable
This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for ERBB3 have been particularly beneficial.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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