Anti-Human ERBB3 Recombinant Antibody (Lumretuzumab) (CAT#: TAB-H47)

This product is a recombinant humanized antibody that recognizes human ERBB3.

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  • Tested Data
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ELISA

Figure 1 Mean ( SD) serum lumretuzumab profiles following single ascending doses from 100 mg up to 2,000 mg for cycle 1.

Figure 1 Mean ( SD) serum lumretuzumab profiles following single ascending doses from 100 mg up to 2,000 mg for cycle 1.

Meulendijks, D., Jacob, W., Martinez-Garcia, M., Taus, A., Lolkema, M. P., Voest, E. E., ... & Sleijfer, S. (2016). First-in-human phase I study of lumretuzumab, a glycoengineered humanized anti-HER3 monoclonal antibody, in patients with metastatic or advanced HER3-positive solid tumors. Clinical Cancer Research, 22(4), 877-885.

Inhib

Figure 2 HER3 expression in a liver lesion biopsy from a patient with colon cancer sampled prior and 14 days after treatment with 400 mg lumretuzumab.

Figure 2 HER3 expression in a liver lesion biopsy from a patient with colon cancer sampled prior and 14 days after treatment with 400 mg lumretuzumab.

The images show intense staining of tumor cell membranes and low cytoplasmic staining in the pre-treatment biopsy with loss of membrane staining.

Meulendijks, D., Jacob, W., Martinez-Garcia, M., Taus, A., Lolkema, M. P., Voest, E. E., ... & Sleijfer, S. (2016). First-in-human phase I study of lumretuzumab, a glycoengineered humanized anti-HER3 monoclonal antibody, in patients with metastatic or advanced HER3-positive solid tumors. Clinical Cancer Research, 22(4), 877-885.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Human IgG1, κ
  • Specificity
  • Human ERBB3
  • Species Reactivity
  • Human
  • Clone
  • Lumretuzumab
  • Applications
  • ELISA, Inhib
  • Conjugate
  • Unconjugated; Biotin; Alexa Fluor 350; Alexa Fluor 405; Alexa Fluor 488; Alexa Fluor 532; Alexa Fluor 594; Alexa Fluor 647; Alexa Fluor 700; Alexa Fluor 750; Biotin; DyLight 350; DyLight 405; DyLight 488; DyLight 550; DyLight 594; DyLight 650; DyLight 680; DyLight 755; FITC; HRP
  • Related Disease
  • Tumor

Product Property

  • Purification
  • Protein A/G purified
  • Storage
  • Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Applications

  • Application Notes
  • The Human ERBB3 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Inhibition.

Target

  • Alternative Names
  • HER3; FERLK; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; human epidermal growth factor receptor 3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Lumretuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lumretuzumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ERBB3"

Single-domain Antibody

Humanized Antibody

CAT Product Name Application Type
TAB-892 Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG2 - lambda
TAB-H22 Anti-Human ERBB3 Recombinant Antibody (Duligotuzumab) (TAB-H22) ELISA, IP, FC, FuncS, Neut, IF, ICC IgG1 - kappa
TAB-057CT Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) Inhibion, ELISA Humanized antibody
TAB-058CT Human Anti-ERBB3 Recombinant Antibody (TAB-058CT) ELISA, Inhib, Cty, IHC, WB, FC Human IgG1, κ
TAB-059CT Anti-Human HER3 Recombinant Antibody (LMAb3) WB, ELISA, Inhibition, FC Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L074E HRGβ2-PE immunotoxin Cytotoxicity assay, Functional assay

Chimeric Antibody

CAT Product Name Application Type
TAB-061CT Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) Inhib, ELISA Chimeric (Rabbit/Human) antibody
TAB-061CT-S(P) Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) Inhib, ELISA Human scFv
TAB-061CT-F(E) Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) Inhib, ELISA Chimeric (Rabbit/Human) Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1179 Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) ICC, IF, WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H21 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-422CQ Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, BL ADCC enhanced antibody
AFC-TAB-189 Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA Human IgG1, κ
AFC-TAB-H22 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-892 Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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