Mouse Anti-ERBB3 Recombinant Antibody (clone 12511) (CAT#: HPAB-0289-YC)
The anti-human erbB3 monoclonal antibody clone 12511 binds with both human erbB3 and mouse erbB3. ERBB3 is a single pass type transmembrane protein which belongs to epidermal growth factor receptor (EGFR) family.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FuncS
Figure 1 shows the antitumor effect of the anti-human erbB3 antibody in a human breast cancer cell line T47D-grafted mouse model.
The abscissa shows the number of days after the tumor grafting, and the ordinate shows the tumor volume. "□" indicates an anti-DNP antibody as a control, "♦" indicates a 1153 antibody, "∘" indicates a 12511 antibody, "X" indicates a 920104 antibody, "Δ" indicates a 1126 antibody, and "●" indicates a U1-59 antibody.
FuncS
Figure 2 shows combinational effect of the anti-human erbB3 antibodies in the human squamous carcinoma cell line A431-grafted mouse model.
"□" indicates an anti-DNP antibody as a control, "♦" indicates a 1153+1251 combination antibody (combination antibody of a 1153 antibody and a 12511 antibody), "∘" indicates a 12511+1126 combination antibody (combination antibody of a 12511 antibody and a 1126 antibody), and "X" indicates a 1153+1126 combination antibody (combination antibody of a 1153 antibody and a 1126 antibody). The abscissa shows the number of days after the tumor grafting, and the ordinate shows the tumor volume.
Specifications
- Immunogen
- ErbB3-Fc
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ERBB3
- Species Reactivity
- Human, Mouse
- Clone
- 12511
- Applications
- ELISA, FuncS, FC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Enzyme-linked Immunosorbent Assay, Flow Cytometry, and Functional Assay. For details, refer to Published Data.
Target
- Alternative Names
- Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; P180-ErbB3; P45-SErbB3; P85-SErbB3; EC 2.7.10; MDA-BF-1; C-ErbB-3; C-ErbB3; ErbB3-S; ErbB-3; LCCS2
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Biparatopic Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
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