Anti-EhpA2 (1C1)-Mc-MMAF ADC (MEDI-547) (CAT#: ADC-L023)
This ADC product is composed of an anti-EhpA2 antibody (clone 1C1) conjuagated via a Mc linker to MMAF (1C1-mc-MMAF). It has demonstrated a response in solid tumors treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
Specifications
- Antibody Overview
- Fully human IgG1 monoclonal antibody that binds to EhpA2
- Clone
- 1C1
- Antibody Conjugation
- Human
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
- Alternative Names
- ECK; CTPA; ARCC2; CTPP1; CTRCT6
- Gene ID
- 1969
- UniProt ID
- P29317
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-083 | Human Anti-EPHA2 Recombinant Antibody (clone 1C1); Fab Fragment | ELISA, WB, FuncS | Human Fab |
| HPAB-0336-YC-F(E) | Mouse Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0336-YC-F(E)) | ELISA, FC, FuncS | Mouse Fab |
| HPAB-0337-YC-F(E) | Human Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0337-YC-F(E)) | ELISA, FC, FuncS | Humanized Fab |
| HPAB-0429-FY-F(E) | Human Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0429-FY-F(E)) | FC | Human Fab |
| HPAB-0430-FY-F(E) | Human Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0430-FY-F(E)) | FC | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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