Anti-EhpA2 (1C1)-Mc-MMAF ADC (MEDI-547)
CAT#: ADC-L023
This ADC product is composed of an anti-EhpA2 antibody (clone 1C1) conjuagated via a Mc linker to MMAF (1C1-mc-MMAF). It has demonstrated a response in solid tumors treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
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Specifications
- Antibody Overview
- Fully human IgG1 monoclonal antibody that binds to EhpA2
- Clone
- 1C1
- Antibody Conjugation
- Human
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
- Alternative Names
- ECK; CTPA; ARCC2; CTPP1; CTRCT6
- Gene ID
- 1969
- UniProt ID
- P29317
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 1C1"
- CAT
- Product Name
See other products for "EPHA2"
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|---|---|---|---|
| TAB-381MZ | Anti-Human EPHA2 Recombinant Antibody (LUCA40) | FC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-385MZ-S(P) | Human Anti-EPHA2 Recombinant Antibody; scFv Fragment (TAB-385MZ-S(P)) | ELISA | Humanized scFv |
| TAB-385MZ-F(E) | Human Anti-EPHA2 Recombinant Antibody; Fab Fragment (TAB-385MZ-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
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| MHC-LC145 | PE-A*02:01/Human EphA2 (TLADFDPRV) MHC Tetramer | FCM | |
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| CAT | Product Name | Application | Type |
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| MOR-1164 | Hi-Affi™ Rabbit Anti-EPHA2 Recombinant Antibody (clone DS1164AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0450-CN-F(E) | Mouse Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0450-CN-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| HPAB-0452-CN-F(E) | Human Anti-EPHA2 Recombinant Antibody; Fab Fragment (HPAB-0452-CN-F(E)) | ELISA, WB, FC, IP | Humanized Fab |
| HPAB-0453-CN-F(E) | Human Anti-EPHA2 Recombinant Antibody (clone 4H5); Fab Fragment | ELISA, FC, IF | Humanized Fab |
| HPAB-0454-CN-F(E) | Human Anti-EPHA2 Recombinant Antibody (clone 2A4); Fab Fragment | ELISA, FC, IF, Agonist | Humanized Fab |
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| MOB-026CQ | Mouse Anti-EPHA2 Recombinant Antibody (clone YC040) | ELISA, WB, IF | Mouse IgG |
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| HPAB-0774-FY | Human Anti-EPHA2 Recombinant Antibody (HPAB-0774-FY) | ELISA | Human IgG |
| HPAB-0775-FY | Human Anti-EPHA2 Recombinant Antibody (HPAB-0775-FY) | ELISA | Human IgG |
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| CAT | Product Name | Application | Type |
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| HPAB-M0068-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone D2-1A7); scFv Fragment | Inhib | Human scFv |
| HPAB-M0069-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone TS1); scFv Fragment | FC | Human scFv |
| HPAB-M0070-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone Ab2); scFv Fragment | FC | Human scFv |
| HPAB-M0071-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone Ab3); scFv Fragment | FC | Human scFv |
| HPAB-0526YY-S(P) | Mouse Anti-EPHA2 Recombinant Antibody (clone A-201); scFv Fragment | ELISA, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY25 | Rabbit Anti-EPHA2 Agonistic Antibody (VS-0724-XY25) | WB, ELISA, FC, IF, Agonistic assays | Rabbit IgG, kappa |
| VS-0724-XY26 | Human Anti-EPHA2 Agonistic Antibody (clone 1C1) | WB, ELISA, FC, IF, Agonistic assays | Human IgG1, kappa |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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