Anti-Mouse Emb Recombinant Antibody (2G21)
CAT#: TAB-328MZ
This antibody 2G21 showing cytotoxicity or a cytotoxicity inducing activity provides a potentially agent for the prophylaxis or therapy of autoimmune diseases or allergic diseases.
Published Data
Gene Expression
FC
Figure 1 is a figure shows evaluation of a binding activity of an anti-Embigin antibody to mouse Embigin expressing rat cells and rat cells by flow cytometry.
Isotype (rat IgG) relative to the anti-Embigin antibody was 5 μg/mL concentration, and a culture supernatant was used as the anti-Embigin antibody (anti-emb antibody).
FuncS
Figure 2 is a figure shows evaluation of cell depletion specificity of a toxin-modified anti-Embigin antibody in pathogenic cells.
FuncS
Figure 3 is a figure shows evaluation of the clinical score of a multiple sclerosis model by transferring cells after selectively depleting Th17 cells with an anti-Embigin antibody into a mouse.
FuncS
Figure 4 is a figure shows evaluation of an efficacy, on clinical score, of administration of, before onset of pathology, an anti-Embigin antibody to a mouse induced to make a multiple sclerosis model by immunizing with PLP.
PLP was mixed with Freund's complete adjuvant and subcutaneously immunized once. The anti-Embigin antibody (300 μg) was administered twice on days 7 and 14 (shown by arrows) after immunization. The clinical score was evaluated until day 18 after PLP immunization.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000170571-EMB
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Specifications
- Immunogen
- Mouse Embigin overexpressing cells
- Host Species
- Rat
- Specificity
- Mouse
- Clone
- 2G21
- Applications
- FC, FuncS
- Related Disease
- Multiple sclerosis, psoriasis, rheumatism, chronic noninfectious uveitis, and glomerulonephritis
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytotoxicityometry, Functional Assay.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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