This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM dI-IgG (FN>AQ)-ala to IL2 (D20T). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2. The Ig-moiety for this IL-2 (D20T) fusion protein was derived from the constant region of an IgG γ4 subclass, which in addition retained features of the IgG γ1 hinge. Furthermore, mutations that remove potential T-cell epitopes were introduced. Additionally, this fusion protein contains the substitution from asparagine to glutamine, which eliminates the N-glycosylation site in Fc. The concomitant substitution of a phenylalanine to alanine removes the potential T-cell epitope. This immunocytokine was designed for treating solid tumor.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-106 | Anti-Human EPCAM Recombinant Antibody (Adecatumumab) | FC, IHC, FuncS, Inhib, Cyt | IgG1 |
TAB-356MZ | Anti-Human EPCAM Recombinant Antibody (3-171) | Cyt, ELISA, FC, WB | Human antibody |
TAB-357MZ | Anti-Human EPCAM Recombinant Antibody (7-F17) | ELISA | Human antibody |
TAB-358MZ | Anti-Human EPCAM Recombinant Antibody (12-C15) | ELISA | Human antibody |
TAB-359MZ | Anti-Human EPCAM Recombinant Antibody (16-G5) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-112-F(E) | Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Fab - G1 - kappa |
TAB-235CL | Human Anti-Human EPCAM Recombinant Antibody (3622W94) | Cyt, FC | Antibody |
TAB-362MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (3622W94) | Confocal, ELISA | Humanized antibody |
TAB-374MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (h12H8B) | FC, ELISA | Humanized antibody |
TAB-375MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (h12H8C) | FC, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L013E | anti-EPCAM immunotoxin MOC31 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L013D | anti-EPCAM immunotoxin MOC31 (IgG)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L013G | anti-EPCAM immunotoxin MOC31 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L013R | anti-EPCAM immunotoxin MOC31 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L013O | anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0531CL-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (HE2) | ELISA, Inhib | |
TAB-363MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-363MZ) | ELISA, FuncS | Mouse IgG1, κ |
TAB-364MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-364MZ) | FC | Mouse IgG1 |
TAB-365MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-365MZ) | FC | Mouse IgG1 |
TAB-366MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-366MZ) | ELISA, FC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1163 | Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) | IHC-P, WB, ICC, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0095-YC-S(P) | Mouse Anti-EPCAM Recombinant Antibody (clone MOC31); scFv Fragment | ELISA | Mouse scFv |
HPAB-0639-YJ-S(P) | Mouse Anti-EPCAM Recombinant Antibody (clone ch FU-MK-1); scFv Fragment | ELISA, FC, WB | Mouse scFv |
HPAB-S0025-YC-S(P) | Mouse Anti-EPCAM Recombinant Antibody (clone M79); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-S0026-YC-S(P) | Human Anti-EPCAM Recombinant Antibody (clone H79); scFv Fragment | ELISA, FC, Cyt | Human scFv |
HPAB-2051-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone 02-237); scFv Fragment | FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-106 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-213 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS | ADCC enhanced antibody |
AFC-TAB-701 | Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2218LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) | ELISA | Human Fab |
HPAB-2219LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) | ELISA | Human Fab |
HPAB-2220LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2220LY-F(E)) | ELISA | Human Fab |
HPAB-2221LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2221LY-F(E)) | ELISA | Human Fab |
HPAB-2222LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2222LY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2216LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2216LY) | ELISA | Human IgG |
HPAB-2217LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2217LY) | ELISA | Human IgG |
HPAB-2218LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2218LY) | ELISA | Human IgG |
HPAB-2219LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2219LY) | ELISA | Human IgG |
HPAB-2220LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2220LY) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0031 | APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM | |
MHC-CN0032 | PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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