Anti-EpCAM Antibody-Cytokine Fusion Protein, dI-IgG (FN>AQ)-ala (huKS)-IL2 (D20T) (CAT#: ACFP-SH071)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM dI-IgG (FN>AQ)-ala to IL2 (D20T). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2. The Ig-moiety for this IL-2 (D20T) fusion protein was derived from the constant region of an IgG γ4 subclass, which in addition retained features of the IgG γ1 hinge. Furthermore, mutations that remove potential T-cell epitopes were introduced. Additionally, this fusion protein contains the substitution from asparagine to glutamine, which eliminates the N-glycosylation site in Fc. The concomitant substitution of a phenylalanine to alanine removes the potential T-cell epitope. This immunocytokine was designed for treating solid tumor.

Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • EpCAM
  • Molecule Class
  • L Kappa; dI-IgG4 (FN>AQ)-ala-IL2 (D20T)
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • huKS
  • Related Disease
  • Solid tumors
  • Cytokine 1
  • IL2 (D20T)
  • Cytokines 1 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component; chromosome 4; surface marker (35kD glycoprotein)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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