This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM scFv-CH1; scFv-Cκ to IL2 and GM-CSF. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of IL2 and GM-CSF. The bi-antibody-cytokine fusion protein exhibited the ability to bind the targeted antigen and retained the biological activity of murine IL2 and GM-CSF to induce CTLL-2 and FDC-P1 cell proliferation respectively. DCH induced human PBMC and T-cell-mediated cytotoxicity of Kato III cells (from a human gastric carcinoma that over-express the EpCAM antigen). This Immunocytokines was designed for treating EpCAM over-expressing cancers.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-701 | Anti-Human EpCAM/17-1A Recombinant Antibody (Edrecolomab) | ELISA, IP, FC, FuncS, IF, Neut | IgG2a - kappa |
TAB-0531CL | Anti-Human EPCAM Recombinant Antibody (HE2) | ELISA, Inhib | |
TAB-0531CL-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (HE2) | ELISA, Inhib | |
TAB-363MZ-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-363MZ-S(P)) | Confocal, ELISA | Mouse scFv |
TAB-364MZ-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-364MZ-S(P)) | NIR (Near-infrared) fluorescence imaging, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-213 | Humanized Anti-EPCAM Recombinant Antibody (clone Tucotuzumab) | WB, Neut, ELISA, IF, IP, FuncS, FC | Humanized (from mouse) IgG1 |
TAB-235CL | Human Anti-Human EPCAM Recombinant Antibody (3622W94) | Cyt, FC | Antibody |
TAB-374MZ | Anti-Human EPCAM Recombinant Antibody (h12H8B) | FC, ELISA | Humanized antibody |
TAB-375MZ | Anti-Human EPCAM Recombinant Antibody (h12H8C) | FuncS, Inhib | Humanized antibody |
TAB-376MZ | Anti-Human EPCAM Recombinant Antibody (h2D11B) | Cyt, Inhib | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-106 | Anti-Human EPCAM Recombinant Antibody (Adecatumumab) | FC, IHC, FuncS, Inhib, Cyt | IgG1 |
TAB-356MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (3-171) | FC, ELISA | Human antibody |
TAB-357MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (7-F17) | FC, ELISA | Human antibody |
TAB-358MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (12-C15) | FC, ELISA | Human antibody |
TAB-359MZ-S(P) | Anti-Human EPCAM Recombinant Antibody scFv Fragment (16-G5) | FC, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L013E | anti-EPCAM immunotoxin MOC31 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L013D | anti-EPCAM immunotoxin MOC31 (IgG)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L013G | anti-EPCAM immunotoxin MOC31 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L013R | anti-EPCAM immunotoxin MOC31 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L013O | anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1163 | Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) | IHC-P, WB, ICC, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0095-YC-S(P) | Mouse Anti-EPCAM Recombinant Antibody (clone MOC31); scFv Fragment | ELISA | Mouse scFv |
HPAB-AP077-YC-S(P) | Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-AP077-YC-S(P)) | FC, IP | Mouse scFv |
HPAB-1520-FY-F(E) | Mouse Anti-EPCAM Recombinant Antibody (clone 2A9); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-2050-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone K53); scFv Fragment | FC | Human scFv |
HPAB-2051-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone 02-237); scFv Fragment | FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0163CQ | Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54) | ELISA, FC, FuncS | Human IgG1 |
HPAB-2216LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2216LY) | ELISA | Human IgG |
HPAB-2217LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2217LY) | ELISA | Human IgG |
HPAB-2218LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2218LY) | ELISA | Human IgG |
HPAB-2219LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2219LY) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0163CQ-F(E) | Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54); Fab Fragment | ELISA, FC, FuncS | Human Fab |
HPAB-2216LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) | ELISA | Human Fab |
HPAB-2217LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) | ELISA | Human Fab |
HPAB-2218LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) | ELISA | Human Fab |
HPAB-2219LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-106 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-213 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS | ADCC enhanced antibody |
AFC-TAB-701 | Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0031 | APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM | |
MHC-CN0032 | PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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