Anti-Human FAT1 Recombinant Antibody (198.3) (CAT#: TAB-030WM)

A novel tumor targeting antibody directed against colon expressed FAT1 (clone 198.3) potentially used for intracellular negative gold nanoparticles delivery, holding significant potential to improve the treatment of cancer.


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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
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FC

Figure 1 Cell surface detection of FAT1 by FACS analysis.

Figure 1 Cell surface detection of FAT1 by FACS analysis.

Staining of colon cancer cell lines using mAb198.3 (empty blue peak) or isotype control (filled red peak) and detected by PE-labelled goat anti-mouse antibodies.

Pileri, P., Campagnoli, S., Grandi, A., Parri, M., De Camilli, E., Song, C., ... & Cinti, C. (2016). FAT1: a potential target for monoclonal antibody therapy in colon cancer. British journal of cancer,  115(1), 40.

WB

Figure 2 FAT1 silencing assessment by WB in HCT15 cell extracts immunostained with mAb198.3.

Figure 2 FAT1 silencing assessment by WB in HCT15 cell extracts immunostained with mAb198.3.

Pileri, P., Campagnoli, S., Grandi, A., Parri, M., De Camilli, E., Song, C., ... & Cinti, C. (2016). FAT1: a potential target for monoclonal antibody therapy in colon cancer. British journal of cancer,  115(1), 40.

IHC

Figure 3 Fluorescence-activated cell sorting and IHC peptide competition analysis on HCT15 cells or colon cancer tissues, respectively, incubated with mAb198.3 and the 25 mer peptides 1 or 7 and the irrelevant peptide.

Figure 3 Fluorescence-activated cell sorting and IHC peptide competition analysis on HCT15 cells or colon cancer tissues, respectively, incubated with mAb198.3 and the 25 mer peptides 1 or 7 and the irrelevant peptide.

Pileri, P., Campagnoli, S., Grandi, A., Parri, M., De Camilli, E., Song, C., ... & Cinti, C. (2016). FAT1: a potential target for monoclonal antibody therapy in colon cancer. British journal of cancer,  115(1), 40.


Specifications

  • Immunogen
  • Recombinant FAT1 (rFAT1)
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • 198.3
  • Applications
  • FC, WB, IHC
  • Related Disease
  • Colorectal cancer

Applications

  • Application Notes
  • This antibody has been tested for use in Flow Cytometry, Western Blot, Immunohistochemistry. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • FAT; ME5; CDHF7; CDHR8; hFat1; FAT1; FAT atypical cadherin 1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0124-WJ-S(P) Mouse Anti-FAT1 Recombinant Antibody; scFv Fragment (HPAB-0124-WJ-S(P)) IHC, ELISA, WB Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0124-WJ-F(E) Mouse Anti-FAT1 Recombinant Antibody; Fab Fragment (HPAB-0124-WJ-F(E)) IHC, ELISA, WB Mouse Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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