Recombinant Anti-human FGFR2 Intrabody [Tat] (CAT#: IAB-B026(T))
Recombinant anti-FGFR2 intrabody in fusion with HIV Tat works within cells to bind intracellur protein FGFR2, expressed in CHO cells.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
Figure 3 IHC staining of human skin
(Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
(Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
Figure 5 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, BEWO, CACO-2, HaCaT, HAP1, NTERA-2, T-47d)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
Specifications
- Immunogen
- human fibroblast growth factor receptor 2
- Host Species
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Products can be used for: Immunocytochemistry; Neutralization; Functional studies
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein;
- Gene ID
- 2263
- UniProt ID
- P21802
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1370z | Mouse Anti-FGFR2 Recombinant Antibody (clone 5F10) | ELISA, IHC, WB | Mouse IgG2b, κ |
| MRO-0580-CN | Mouse Anti-FGFR2 Recombinant Antibody (clone 1-F1-E7) | WB, IF, FC | Mouse IgG1 |
| MRO-0581-CN | Mouse Anti-FGFR2 Recombinant Antibody (clone A5-E10-G7) | WB, IF, IHC | Mouse IgG1 |
| HPAB-AP348-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-AP348-YC) | ELISA, FC, Neut, ADCC, FuncS | Chimeric (rat/human) IgG |
| HPAB-AP349-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-AP349-YC) | ELISA, FC, Neut, ADCC, FuncS | Chimeric (rat/human) IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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