Human Anti-FGFR2 Recombinant Antibody (clone Hu4B9-65) (CAT#: HPAB-0144-YC)
Monoclonal antibodies that bind and inhibit biological activities of human FGFR2 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation or overexpression of FGFR2.
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Inhib
Figure 1 a graph Summarizing results from an experiment to measure inhibition of proliferation of FDCP-1 cells expressing wild type FGFR2-IIIb by treatment with antibody 4B9, Hu4B9-65, Hu4B9-82 and Hu4B9-83.
Humanized antibodies (HuAB9-65. Hu4B9-82, and Hu4B9-83) demonstrated dose-dependent inhibition of FGF1-induced FDCP-FGFR2-IIIb cell prolif eration. The average IC50s of the 4B9, HuAB9-65, Hu4B9-82 and Hu4B9-83 from three independent experiments are 1.4.4.9, 5.7 and 4.7 nM, respectively.
Specifications
- Immunogen
- Mixture of human FGFR2 IgD2-IgD3 (IIIb) and human FGFR2 IgD2-IgD3 (IIIc) fused with a human Fc moiety at their C-termini
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG1, κ
- Specificity
- Human FGFR2
- Species Reactivity
- Human
- Clone
- Hu4B9-65
- Applications
- FuncS
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Inhibition. For details, refer to Published Data.
Target
- Alternative Names
- Fibroblast Growth Factor Receptor 2; Keratinocyte Growth Factor Receptor; Bacteria-Expressed Kinase; EC 2.7.10.1; K-SAM; KGFR; BEK; Protein Tyrosine Kinase, Receptor Like 14; BEK Fibroblast Growth Factor Receptor; Craniofacial Dysostosis 1; Jackson-Weiss Syndrome; Pfeiffer Syndrome; Crouzon Syndrome; CD332 Antigen; EC 2.7.10; FGFR-2; BFR-1; CD332; BBDS; CEK3; ECT1; TK14; TK25; CFD1; KSAM; JWS
- Gene ID
- 2263
- UniProt ID
- P21802
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B026(A) | Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B026(G) | Recombinant Anti-human FGFR2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B026(T) | Recombinant Anti-human FGFR2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
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