The antibodies are specific for vascular endothelial growth factor receptor-1 (VEGFR-I) and methods of treating angiogenesis-associated diseases and tumors with antibodies to VEGFR-I.
Figure 1 VEGF-A or -B enhances CRC cell migration
Effect of VEGF-A or -B on CRC cell migration.(a) HT-29 cells were treated with the anti-VEGFR-1 antibody 18F1 and used for transwell migration assays. At 48 h, incubation with VEGF-A or -B significantly increased cell migration, but treatment with the VEGFR-1 antibody blocked this effect. *P<0.0001 vs control cells; bars indicate s.e.m. Similar results were observed in SW480 cells (data not shown).(b) Photographs of migrated cells
Fan, F., Wey, J. S., McCarty, M. F., Belcheva, A., Liu, W., Bauer, T. W.,... & Ellis, L. M. (2005). Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene, 24(16), 2647.
Figure 2 VEGF-A or -B enhances CRC cell invasion
Effect of VEGF-A or -B on CRC cell invasion. (a) SW480 cells were treated with the anti-VEGFR-1 antibody 18F1 and transwell invasion assays were performed. At 48 h, incubation with VEGF-A or -B increased cell invasion, but treatment with the VEGFR-1 antibody completely blocked this effect. *P<0.05 vs control cells; bars indicate s.e.m. (b) Photographs of invaded cells
Fan, F., Wey, J. S., McCarty, M. F., Belcheva, A., Liu, W., Bauer, T. W.,... & Ellis, L. M. (2005). Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene, 24(16), 2647.
Figure 3 VEGF-A or VEGF-B enhances CRC cell growth in soft agar
Effect of VEGF-A or -B on colony formation in soft agar.(a) HT29 cells were plated in soft agar with or without VEGF-A, -B, or VEGFR-1 antibody (18F1), and colonies were counted 14 days later. Cells treated with VEGF-A or -B formed more and larger colonies than controls; addition of VEGFR-1 antibody decreased colony formation induced by the VEGF ligands. *P<0.03 vs control cells; bars indicate s.e.m.(b) Photographs of colony formation.
Fan, F., Wey, J. S., McCarty, M. F., Belcheva, A., Liu, W., Bauer, T. W.,... & Ellis, L. M. (2005). Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene, 24(16), 2647.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-177 | Anti-Human VEGFR-1 Recombinant Antibody (Icrucumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-008CQ | Mouse Anti-FLT1 Recombinant Antibody (TAB-008CQ) | ELISA, FC | Mouse IgG |
TAB-008CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-008CQ-S(P)) | ELISA, FC | Mouse scFv |
TAB-008CQ-F(E) | Mouse Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-008CQ-F(E)) | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-009CQ | Human Anti-FLT1 Recombinant Antibody (TAB-009CQ) | ELISA | Chimeric antibody (mouse/human) |
TAB-009CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-009CQ-S(P)) | ELISA | Mouse scFv |
TAB-009CQ-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-009CQ-F(E)) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-845CQ | Mouse Anti-FLT1 Recombinant Antibody (clone MAB0702) | WB, Block | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1322 | Hi-Affi™ Rabbit Anti-FLT1 Recombinant Antibody (clone DS1322AB) | WB, IHC-P, ICC, IF, IP, ELISA, IHC-P, IHC-Fr | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0137-YC-F(E) | Human Anti-FLT1 Recombinant Antibody (clone 18F1); Fab Fragment | ELISA, FC, Block, WB | Human Fab |
HPAB-0785-CN-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527); Fab Fragment | ELISA, FC | Mouse Fab |
HPAB-1606LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1606LY-F(E)) | ELISA | Human Fab |
HPAB-1607LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1607LY-F(E)) | ELISA | Human Fab |
HPAB-1609LY-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (HPAB-1609LY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1606LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1606LY) | ELISA | Human IgG |
HPAB-1607LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1607LY) | ELISA | Human IgG |
HPAB-1609LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1609LY) | ELISA | Human IgG |
HPAB-1610LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1610LY) | ELISA | Human IgG |
HPAB-1611LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1611LY) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-177 | Afuco™ Anti-FLT1 ADCC Recombinant Antibody (Icrucumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0673 | PE-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
MHC-CN0674 | APC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
MHC-CN0675 | FITC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
MHC-CN1412 | PE-A*24:02/Human FLT1 (SYGVLLWEI) MHC Tetramer | FCM | |
MHC-YF771 | A*02:01/Human VEGFR1 (GVLLWEIFSL) MHC Pentamer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1699-FY-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone CA0071-Z2ZM-01941); scFv Fragment | ELISA | Mouse scFv |
HPAB-1700-FY-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone CA0071-Z2ZA-01171); scFv Fragment | ELISA | Mouse scFv |
HPAB-1701-FY-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone CA0071-Z2ZB-01171); scFv Fragment | ELISA | Mouse scFv |
HPAB-1702-FY-F(E) | Human Anti-FLT1 Recombinant Antibody (clone 6F9); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1703-FY-F(E) | Human Anti-FLT1 Recombinant Antibody (clone 13G12); scFv Fragment | ELISA, WB | Human scFv |
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