Recombinant Anti-human FOLR1 Intrabody [(D-Arg)₉]

Name: Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9]
SKU: IAB-B029(A)
Rating: 5 (1 reviews)

CAT#: IAB-B029(A)

Recombinant anti-FOLR1 intrabody linked to (D-Arg)₉ works within cells to bind FOLR1, which is selectively overexpressed in 90% of nonmucinous ovarian carcinomas, expressed in CHO cells. FR expression is associated with tumor progression and affects cell proliferation and the intracellular expression of single-chain (sc) antibodiess (intrabody) can downmodulate membrane expression of FR in ovary cancer cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HeLa

Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1

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Specifications

Immunogen
human folate receptor 1 (adult)

Host Species
mouse

Type
scFv-(D-Arg)₉

Cell Penetrating Peptide
(D-Arg)₉
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.

Species Reactivity
human

Applications
Can be useful in applications such as: Protein fragment complementation; Neutralization; Functional studies

Product Property

Purity
>98% by SDS-PAGE and HPLC analysis

Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Target

Alternative Names
FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18

Gene ID
2348

UniProt ID
A0A024R5H1

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - IAB-B029(A).pdf

MSDS

MSDS - IAB-B029(A).pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
TAB-017CQ	Rat Anti-FOLR1 Recombinant Antibody (TAB-017CQ)	ELISA, WB, IHC	Rat IgG1, κ
TAB-017CQ-S(P)	Rat Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-017CQ-S(P))	ELISA, WB, IHC	Rat scFv
TAB-020CQ-S(P)	Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-020CQ-S(P))	ELISA, FC, WB, IHC	Mouse scFv
TAB-017CQ-F(E)	Rat Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-017CQ-F(E))	ELISA, WB, IHC	Rat Fab
TAB-020CQ-F(E)	Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-020CQ-F(E))	ELISA, FC, WB, IHC	Mouse Fab

CAT	Product Name	Application	Type
TAB-018CQ	Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ)	ELISA, WB, IHC	Chimeric (Rat/Human) IgG1, κ
TAB-018CQ-S(P)	Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P))	ELISA, WB, IHC	Human scFv
TAB-018CQ-F(E)	Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E))	ELISA, WB, IHC	Chimeric (Rat/Human) Fab

CAT	Product Name	Application	Type
TAB-016CQ-S(P)	Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-016CQ-S(P))	ELISA, FC, WB	Human scFv
TAB-016CQ-F(E)	Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-016CQ-F(E))	ELISA, FC, WB	Human Fab
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TAB-382CQ-S(P)	Anti-Human FOLR1 Recombinant Antibody scFv Fragment (TAB-382CQ-S(P))	IHC	Human antibody
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CAT	Product Name	Application	Type
Gly-029LC-1	Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
HPAB-0117-CN-F(E)	Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0117-CN-F(E))	ELISA, FC	Mouse Fab
HPAB-0118-CN-F(E)	Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0118-CN-F(E))	ELISA, FC	Mouse Fab
HPAB-0119-CN-F(E)	Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0119-CN-F(E))	ELISA, FC, IHC, WB	Mouse Fab
HPAB-0120-CN-F(E)	Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0120-CN-F(E))	ELISA, FC, IHC, WB	Mouse Fab
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
HPAB-0312-WJ-S(P)	Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0312-WJ-S(P))	ELISA, IHC, FC	Mouse scFv
HPAB-0313-WJ-S(P)	Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0313-WJ-S(P))	ELISA, IHC, FC	Mouse scFv
HPAB-0314-WJ-S(P)	Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0314-WJ-S(P))	ELISA, IHC, FC	Mouse scFv
HPAB-M0094-YC-S(P)	Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-M0094-YC-S(P))	FuncS	Humanized scFv
HPAB-N0093-YC-S(P)	Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-N0093-YC-S(P))	ELISA	Humanized scFv

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MHC-CN0050	PE-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer	FCM
MHC-CN0685	PE-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer	FCM, IHC
MHC-CN0686	APC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer	FCM, IHC
MHC-CN0687	FITC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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