Recombinant Anti-human FOLR1 Intrabody [Tat] (CAT#: IAB-B029(T))
Recombinant anti-FOLR1 intrabody in fusion with HIV Tat works within cells to bind FOLR1, which is selectively overexpressed in 90% of nonmucinous ovarian carcinomas, expressed in CHO cells. FR expression is associated with tumor progression and affects cell proliferation and the intracellular expression of single-chain (sc) antibodiess (intrabody) can downmodulate membrane expression of FR in ovary cancer cells.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Specifications
- Immunogen
- human folate receptor 1 (adult)
- Host Species
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Antibody assay: Western blot; Immunocytochemistry; Neutralization; Functional studies
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- 4°C or -20°C, avoid repeated freezing and thawing.
Target
- Alternative Names
- FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18
- Gene ID
- 2348
- UniProt ID
- A0A024R5H1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1297z | Mouse Anti-FOLR1 Recombinant Antibody (clone 24A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2a |
| HPAB-0115-CN | Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0115-CN) | ELISA, FC, IHC | Mouse IgG2b |
| HPAB-0116-CN | Human Anti-FOLR1 Recombinant Antibody (HPAB-0116-CN) | ELISA, FC, IHC | Humanized IgG1 |
| HPAB-M0094-YC | Human Anti-FOLR1 Recombinant Antibody (HPAB-M0094-YC) | FuncS | Humanized IgG |
| VS-0723-WK144 | Human Anti-FOLR1 Recombinant Antibody (VS-0723-WK144) | FC | Chimeric (rabbit/human) IgG1 |
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