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    Recombinant Anti-human FOLR1 Intrabody [Tat] (CAT#: IAB-B029(T))

    Recombinant anti-FOLR1 intrabody in fusion with HIV Tat works within cells to bind FOLR1, which is selectively overexpressed in 90% of nonmucinous ovarian carcinomas, expressed in CHO cells. FR expression is associated with tumor progression and affects cell proliferation and the intracellular expression of single-chain (sc) antibodiess (intrabody) can downmodulate membrane expression of FR in ovary cancer cells.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HeLa
    Figure 1 IF staining of human cell line HeLa
    (Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
    RNA Expression
    Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
    Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
    Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
    Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1

    Specifications

    • Immunogen
    • human folate receptor 1 (adult)
    • Host Species
    • mouse
    • Type
    • scFv-Tat
    • Cell Penetrating Peptide
    • TAT
      TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
    • Species Reactivity
    • human
    • Applications
    • Antibody assay: Western blot; Immunocytochemistry; Neutralization; Functional studies

    Product Property

    • Purity
    • >95% as judged by SDS-polyacrylamide gel electrophoresis
    • Storage
    • 4°C or -20°C, avoid repeated freezing and thawing.

    Target

    • Alternative Names
    • FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

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    IgG Antibody Products Intrabody Products Humanized Antibody Products Human Antibody Products Mouse Antibody Products Chimeric Antibody Products Fc Glycosylation Antibody Products Low- or Non-fucosylated Oligosaccharide Antibody Products Rabbit Monoclonal Antibody Products ScFv Antibody Products Fab Antibody Products ADCC Enhanced Antibody Products MHC Tetramer Products for Cancer ScFv-Fc Chimera Products Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    MOB-1297z Mouse Anti-FOLR1 Recombinant Antibody (clone 24A8) WB, ELISA, FC, ICC, IF, IHC Mouse IgG2a
    HPAB-0115-CN Mouse Anti-FOLR1 Recombinant Antibody (HPAB-0115-CN) ELISA, FC, IHC Mouse IgG2b
    HPAB-0116-CN Human Anti-FOLR1 Recombinant Antibody (HPAB-0116-CN) ELISA, FC, IHC Humanized IgG1
    HPAB-M0094-YC Human Anti-FOLR1 Recombinant Antibody (HPAB-M0094-YC) FuncS Humanized IgG
    VS-0723-WK144 Human Anti-FOLR1 Recombinant Antibody (VS-0723-WK144) FC Chimeric (rabbit/human) IgG1

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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