Recombinant Anti-human FOLR1 Intrabody [Tat] (CAT#: IAB-B029(T))

• Immunogen
• human folate receptor 1 (adult)

• Host Species
• mouse

• Type
• scFv-Tat

• Cell Penetrating Peptide
• TAT
  TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

• Species Reactivity
• human

• Applications
• Antibody assay: Western blot; Immunocytochemistry; Neutralization; Functional studies

• Purity
• >95% as judged by SDS-polyacrylamide gel electrophoresis

• Storage
• 4°C or -20°C, avoid repeated freezing and thawing.

• Alternative Names
• FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18

• Gene ID
• 2348

• UniProt ID
• A0A024R5H1

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