anti-FUT3 immunotoxin BR96 (scFv)-PE
CAT#: AGTO-L055E
This immunotoxin was achieved by conjugating/fusing the Anti-FUT3 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Vascular leak syndrome cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Vascular leak syndrome.
Gene Expression
Normal Tissue
Figure 1 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_A_6_6.jpg
Normal Tissue
Figure 2 Colon
Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Goblet cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_A_7_5.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_B_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A-431, hTCEpi, OE19, RH-30, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171124-FUT3
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- BR96
- Molecule Class
- scFv-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Vascular leak syndrome
Target
- Alternative Names
- FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase; Vascular leak syndrome; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MSDS
COA
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See other products for "Clone BR96"
- CAT
- Product Name
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Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1628z | Mouse Anti-FUT3 Recombinant Antibody (clone 5H6) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0258CT | Recombinant Mouse anti-Human FUT3 Monoclonal antibody (3-36MF) | ELISA, ICC, IF, IHC-P, WB | |
| FAMAB-1370CQ | Human Anti-FUT3 Recombinant Antibody (clone PR 5C5) | ELISA, IF, IHC | Human IgG1 |
| VS2-QX87 | Mouse Anti-FUT3 Recombinant Antibody (clone MAL A) | Haemagglutination | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L017E | anti-FUT3 immunotoxin BR96 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L017R | anti-FUT3 immunotoxin BR96 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L055R | anti-FUT3 immunotoxin BR96 (scFv)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS2-QX25 | Mouse Anti-FUT3 Recombinant Antibody (clone BRIC 87) | ICC, IF, WB | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC703 | Recombinant Anti-FUT3 Vesicular Antibody, EV Displayed (VS-0425-YC703) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2673 | Anti-FUT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2674 | Anti-Human FUT3 Immunohistochemistry Kit | IHC |
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