Anti-Human GAD2 Recombinant Antibody (CAT#: TAB-297CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human GAD2. GAD65Ab are common in healthy individuals, but masked by epitope-specific anti-idiotypic antibodiess. GAD65Ab may have a pathogenic role in the disease process in patients with Stiff Person Syndrome (SPS). GAD65Ab in SPS patients inhibit the enzyme's activity and result in a deficit in the major inhibitory neurotransmitter GABA, possibly causing clinical symptoms such as muscle spasms and stiffness.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_B_9_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_B_9_5.jpg
Figure 2 Pancreas
(Pancreatic endocrine cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_A_3_3.jpg
(Pancreatic endocrine cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_A_3_3.jpg
Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136750-GAD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136750-GAD2
Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136750-GAD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136750-GAD2
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Diabetes Type 1
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); GAD65; glutamate decarboxylase 2; GAD-65; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform
- Gene ID
- 2572
- UniProt ID
- Q05329
Related Resources
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "GAD2"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0421ZL | Rabbit anti-GAD2 polyclonal Antibody | WB | |
| MOB-2430MZ | Recombinant Mouse Anti-Rat GAD2 Antibody (clone HBE-7) | IHC-FoFr, IHC-Fr, IHC-P, WB | Mouse antibody |
| HPAB-1982-FY | Human Anti-GAD2 Recombinant Antibody (clone b78) | Inhib | Human IgG1, λ |
| VS3-QX454 | Mouse Anti-GAD2 Recombinant Antibody (clone 6D5-E8-E4) | WB | Mouse IgG2b |
| VS3-QX455 | Mouse Anti-GAD2 Recombinant Antibody (clone 458CT17.2.4) | WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1389 | Hi-Affi™ Rabbit Anti-GAD2 Recombinant Antibody (clone DS1389AB) | WB | Rabbit IgG |
MHC Tetramer for Cancer
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1982-FY-F(E) | Human Anti-GAD2 Recombinant Antibody (clone b78); Fab Fragment | Inhib | Human Fab, λ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1982-FY-S(P) | Human Anti-GAD2 Recombinant Antibody (clone b78); scFv Fragment | Inhib | Human scFv |
MHC Tetramer for Other Applications
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF030 | DRB1*04:01/Human GAD65 (IAFTSEHSHFSLK) MHC Monomer | MHC Multimer | |
| MHC-YF033 | DRB1*04:01/Human GAD65 (NFIRMVISNPAAT) MHC Monomer | MHC Multimer | |
| MHC-YF034 | DRB1*04:01/Human GAD65 (DVMNILLQYVVKSFDRSTKV) MHC Monomer | MHC Multimer | |
| MHC-YF035 | DRB1*04:01/Human GAD65 (KGMAALPRLIAFTSEHSHFS) MHC Monomer | MHC Multimer |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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