Anti-GD2 Immunocytokine, IgG (14.18)-IL12-IL2 (ACFP-SH176)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to IL12 and IL2. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the GD2 as well as the biological activity of IL12 and IL2. The goal of this antibody-cytokine fusion protein to cancer therapy is to concentrate the cytokine in the tumor microenvironment and in so doing directly enhance the tumoricidal effect of the antibody and/or enhance the host immune response (T-cell, B-cell or NK) against the tumor. This Immunocytokines was designed for treating neuroblastomas, medulloblastomas, astrocytomas, melanomas, small-cell lung cancer, osteosarcomas and other soft tissue sarcomas. .      

Molecule Class
Species Reactivity
Expression Host
Related Disease
Neuroblastomas, Medulloblastomas, Astrocytomas, Melanomas, Small-cell lung cancer, Osteosarcomas and other soft tissue sarcomas.
Cytokines 1
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Cytokines 2
Cytokines 2 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 2 Species
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Alternative Names
Disialoganglioside GD2; Ganglioside G2; GD2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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