Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (14.18)-IL12-IL2 (CAT#: ACFP-SH178)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to IL12 and IL2. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the GD2 as well as the biological activity of IL12 and IL2. The fusion proteins comprise a heterodimeric form of IL-12 in which the p35 and p40 subunits of IL-12 are linked by a disulfide bond and covalently bonded to a secondcytokine at either the amino or carboxyl terminus of the p35 or p40 subunit of IL-12. This Immunocytokines was designed for treating neuroblastomas, medulloblastomas, astrocytomas, melanomas, small-cell lung cancer, osteosarcomas and other soft tissue sarcomas. .


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Specifications

  • Target
  • GD2
  • Molecule Class
  • L kappa; IgG1-IL12-IL2
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • 14.18
  • Related Disease
  • Neuroblastomas, Medulloblastomas, Astrocytomas, Melanomas, Small-cell lung cancer, Osteosarcomas and other soft tissue sarcomas.
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Cytokine 2
  • IL2
  • Cytokines 2 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 2 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • Disialoganglioside GD2; Ganglioside G2; GD2

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Single-domain Antibody

CAT Product Name Application Type
NAB-770-sdAb Recombinant Anti-Human GD2 VHH Single Domain Antibody Neut, ChiP, IP, FUNC Llama VHH

Chimeric Antibody

CAT Product Name Application Type
TAB-731 Anti-GD2 Recombinant Antibody (Dinutuximab) Neut, ELISA, IF, IP, FuncS, FC, ICC IgG1 - kappa

Immunotoxin

CAT Product Name Application Type
AGTO-L018R anti-GD2 immunotoxin 14G2a (IgG)-RTA Cytotoxicity assay, Functional assay

Recombinant Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-731 Afuco™ Anti-GD2 ADCC Recombinant Antibody (Dinutuximab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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