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    Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-GM-CSF

    CAT#: ACFP-SH021

    This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of GM-CSF. This antibody-cytokine fusion protein retains the ability to induce ADCC and CDC activity. The fusion of GM-CSF to the antibody increased its cytotoxicity against NMB7 neuroblastoma cells by granulocytes isolated from neuroblastoma patients, and increased ADCC-mediated by mononuclear cells from the same patients, in comparison with ch14.18 alone. This immunocytokine was designed for treating GD2-positive tumors.

    Specifications

    • Target
    • GD2
    • Molecule Class
    • IgG1-GM-CSF
    • Species Reactivity
    • Human
    • Expression Host
    • CHO
    • Clone
    • ch14.18
    • Related Disease
    • GD2-positive tumors
    • Cytokine 1
    • GM-CSF
    • Cytokines 1 Description
    • Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called molgramostim.
    • Cytokine 1 Species
    • Human
    • Applications
    • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

    Target

    • Alternative Names
    • Disialoganglioside GD2; Ganglioside G2; GD2
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    Datasheet

    Datasheet - ACFP-SH021.pdf

    MSDS

    MSDS - ACFP-SH021.pdf

    COA

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