Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-GM-CSF (CAT#: ACFP-SH021)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of GM-CSF. This antibody-cytokine fusion protein retains the ability to induce ADCC and CDC activity. The fusion of GM-CSF to the antibody increased its cytotoxicity against NMB7 neuroblastoma cells by granulocytes isolated from neuroblastoma patients, and increased ADCC-mediated by mononuclear cells from the same patients, in comparison with ch14.18 alone. This immunocytokine was designed for treating GD2-positive tumors.
Specific Inquiry
Specifications
- Target
- GD2
- Molecule Class
- IgG1-GM-CSF
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- ch14.18
- Related Disease
- GD2-positive tumors
- Cytokine 1
- GM-CSF
- Cytokines 1 Description
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called molgramostim.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Disialoganglioside GD2; Ganglioside G2; GD2
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone ch14.18"
See other products for "GD2"
Select a product category from the dropdown menu below to view related products.
Please select product type
Single Domain Antibody Products
Chimeric Antibody Products
Immunotoxin Products
Humanized Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Human Antibody Products
IgM Antibody Products
Neuroscience Antibody Products
ADCC Enhanced Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for ACFP-SH021. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: ELISA, Neut, FuncS
Application: ELISA
Application: WB, IHC, ELISA, FC
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IF, Block, FuncS
Application: ELISA, Activ, Block
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
