Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-LT (CAT#: ACFP-SH020)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG via its amino terminal amino acid to carboxy-terminus of LT. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of LT. This immunocytokine was designed for treating GD2-positive tumors.
Specific Inquiry
Specifications
- Target
- GD2
- Molecule Class
- L Kappa; IgG1-LT
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- ch14.18
- Related Disease
- GD2-positive tumors
- Cytokine 1
- LT
- Cytokines 1 Description
- Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. It is also known to be required for normal development of Peyer's patches. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Disialoganglioside GD2; Ganglioside G2; GD2
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-731 | Anti-GD2 Recombinant Antibody (Dinutuximab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L018R | anti-GD2 immunotoxin 14G2a (IgG)-RTA | Cytotoxicity assay, Functional assay |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-304CL | Anti-Human GD2 Recombinant Antibody (hu14.18K322A) | FC, FuncS | Antibody |
| PABX-059 | Human Anti-GD2 Recombinant Antibody (PABX-059) | FuncS | IgG1, κ |
| PABX-059-F (E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (PABX-059-F (E)) | FC, ELISA, FuncS | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a) | ELISA, WB, FuncS | Mouse IgG |
| PABL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8) | FC, ELISA, FuncS | Mouse IgG |
| HPAB-0701-CN | Human Anti-GD2 Recombinant Antibody (clone AB527) | ELISA, FC, IHC, IF | Human IgM |
| HPAB-0027-WJ | Mouse Anti-GD2 Recombinant Antibody (HPAB-0027-WJ) | ELISA, RIA | Mouse IgG3, κ |
| HPAB-1030WJ | Human Anti-GD2 Recombinant Antibody (HPAB-1030WJ) | ELISA | Chimeric (mouse/human) IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| PSBL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8); scFv Fragment | FC, ELISA, FuncS | Mouse scFv |
| HPAB-1030WJ-S(P) | Mouse Anti-GD2 Recombinant Antibody; scFv Fragment (HPAB-1030WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-1524WJ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (clone KM8138) | ELISA, WB | Human scFv |
| HPAB-1525WJ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (clone KM1138) | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| PFBL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8); Fab Fragment | FC, ELISA, FuncS | Mouse Fab |
| PFBZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1); Fab Fragment | WB, FuncS | Mouse Fab |
| FAMAB-0126-YC-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0027-WJ-F(E) | Mouse Anti-GD2 Recombinant Antibody; Fab Fragment (HPAB-0027-WJ-F(E)) | ELISA, RIA | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074CQ | Human Anti-GD2 Recombinant Antibody (TAB-074CQ) | ELISA, FC | Human IgG1, κ |
| TAB-075CQ | Human Anti-GD2 Recombinant Antibody (TAB-075CQ) | ELISA, FC | Human IgM, κ |
| TAB-076CQ | Human Anti-GD2 Recombinant Antibody (TAB-076CQ) | ELISA, FC | Human IgG1, κ |
| TAB-077CQ | Human Anti-GD2 Recombinant Antibody (TAB-077CQ) | ELISA, FC | Human IgG1, κ |
| TAB-078CQ | Human Anti-GD2 Recombinant Antibody (TAB-078CQ) | ELISA, FC | Human IgG1, κ |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-029CN | Mouse Anti-GD2 Recombinant Antibody (clone 5F11) | WB | Mouse IgG |
| NS-030CN | Mouse Anti-GD2 Recombinant Antibody (clone 3G6) | WB | Mouse IgG |
| NS-029CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); Fab Fragment | WB | Mouse Fab |
| NS-030CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 3G6); Fab Fragment | WB | Mouse Fab |
| NS-029CN-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); scFv Fragment | WB | Mouse scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-731 | Afuco™ Anti-GD2 ADCC Recombinant Antibody (Dinutuximab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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