Anti-Human GHR Recombinant Antibody (SS1) (CAT#: TAB-090CQ)
Recombinant monoclonal antibody to GHR. SS1 is a humanized antibody that selectively interacts with and inhibits human GHR function. It can reduce IGF-1 levels. It can be potentially used in the treatment of arthritis.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1366_E6_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1366_E6_2_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1639_F9_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1639_F9_2_blue_red_green.jpg
Figure 3 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1361_E6_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1361_E6_2_blue_red_green.jpg
Figure 4 Colon
(Enterocytes - Microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_7_3.jpg
(Enterocytes - Microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_7_3.jpg
Figure 5 Liver
(Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_8_4.jpg
(Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_8_4.jpg
Figure 6 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (microvilli)
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_9_5.jpg
(Collecting ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (microvilli)
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_9_5.jpg
Figure 7 Testis
(Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_4_6.jpg
(Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_4_6.jpg
Figure 8 RNA cell line category: Group enriched (HSkMC, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112964-GHR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112964-GHR
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Species Reactivity
- Human, Cynomolgus monkey
- Clone
- SS1
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Flow Cytometry
- Related Disease
- Arthritis
Target
- Alternative Names
- GHR; growth hormone receptor; GHBP; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
- Gene ID
- 2690
- UniProt ID
- P10912
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1090-VHH | Recombinant Anti-Human GHR VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
Customer Reviews and Q&As
Customer Review
Q&As
Significant and Stable Signal
We used this product for IF test with a sample that we received three weeks ago. The data was good, demonstrating the success of our methodology and getting expected conclusion.
Good Specificity and Quality
We applied the anti-human GHR recombinant antibody (SS1) to both IF and IHC. The antibody's high affinity for the target antigen ensured stable binding, enhancing the reproducibility of experimental results.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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