Anti-Human GPVI Recombinant Antibody (1C3) (CAT#: TAB-003CT)

Name: Anti-Human GPVI Recombinant Antibody (1C3)
SKU: TAB-003CT
Rating: 5 (1 reviews)

Recombinant monoclonal antibody to GPVI. This antibody intended for the prophylaxis and treatment of Thrombosis and other vascular diseases.

Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

We require custom production

Published Data
Gene Expression
Datasheet
MSDS
COA

Funcs

Figure 1 1C3 potentiates 10B12 inhibition of collagen- and CRP-XL-induced platelet aggregation.

Figure 1 1C3 potentiates 10B12 inhibition of collagen- and CRP-XL-induced platelet aggregation.

Platelet-rich plasma was incubated for 5 min with a titration of monomeric 10B12, with (closed circle) or without (open circle) a saturating concentration (20 μg/ml) of monomeric 1C3. 2.0 μg/ml of fibrillar collagen was added and the rate (C) and extent (D) of aggregation measured. The effect of 20 μg/ml of 1C3 alone in each case is apparent on the y-axis (0 μg/ml 10B12). Results are expressed as percentage of platelet aggregation in the absence of scFvs. Points represent 2-8 determinations from experiments performed on platelets from three individual donors.

O'Connor, M. N., Smethurst, P. A., Davies, L. W., Joutsi-Korhonen, L., Onley, D. J., Herr, A. B., ... & Ouwehand, W. H. (2006). Selective blockade of glycoprotein VI clustering on collagen helices. Journal of Biological Chemistry, 281(44), 33505-33510.

Subcellular Location

Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47611/1925_A11_24_cr5cd55a323d93f_selected.jpg

Normal Tissue

Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/ihc_selected.jpg

Figure 3 Cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_B_9_5.jpg

Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_7_3.jpg

Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_8_5.jpg

Figure 6 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_6_6.jpg

RNA Expression

Figure 7 RNA cell line category: Group enriched (HEL, K-562, U-2 OS)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000088053-GP6

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Host Species
Human

Derivation
Phage display library

Type
Human antibody

Specificity
Human

Species Reactivity
Human

Clone
1C3

Applications
Funcs, ELISA, Inhib, FC

Related Disease
Thrombosis and other vascular diseases

Applications

Application Notes
The GPVI antibody has been reported in applications of Functional Assay, Enzyme-linked Immunosorbent Assay, Inhibition, Flow Cytometry.

Target

Alternative Names
GP6; glycoprotein VI (platelet); GPIV; GPVI; BDPLT11; platelet glycoprotein VI; glycoprotein 6; platelet collagen receptor; 9O12. 2

Gene ID
51206

UniProt ID
Q9HCN6

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT	Product Name	Application	Type
MOB-1438z	Mouse Anti-GP6 Recombinant Antibody (clone 38C4)	WB, ELISA, IF, IP	Mouse IgG2b, κ
HPAB-1711-FY	Human Anti-GP6 Recombinant Antibody (clone F1245-4-1)	ELISA, WB, IHC	Chimeric (mouse/human) IgG
HPAB-1712-FY	Human Anti-GP6 Recombinant Antibody (clone F1245-5-1)	ELISA, WB, IHC	Chimeric (mouse/human) IgG
HPAB-1713-FY	Human Anti-GP6 Recombinant Antibody (clone F1245-6-2)	ELISA, WB, IHC	Chimeric (mouse/human) IgG
VS-0723-WK132	Human Anti-GP6 Recombinant Antibody (VS-0723-WK132)	FC	Chimeric (rabbit/human) IgG1

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CAT	Product Name	Application	Type
TAB-005CT	Mouse Anti-GP6 Recombinant Antibody (TAB-005CT)	WB, ELISA, Block	Mouse IgG1, κ
TAB-005CT-S(P)	Mouse Anti-GP6 Recombinant Antibody; scFv Fragment (TAB-005CT-S(P))	WB, ELISA, Block	Mouse scFv
TAB-005CT-F(E)	Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (TAB-005CT-F(E))	WB, ELISA, Block	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0002-CN-S(P)	Human Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0002-CN-S(P))	FC, WB	Humanized scFv
HPAB-0003-CN-S(P)	Human Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0003-CN-S(P))	FC, WB	Humanized scFv
HPAB-0004-CN-S(P)	Mouse Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0004-CN-S(P))	FC, WB	Mouse scFv
HPAB-0133CQ-S(P)	Human Anti-GP6 Recombinant Antibody (clone hGP 5C4); scFv Fragment	ELISA, FC, Inhib, FuncS	Humanized scFv
FAMAB-0101JF-S(P)	Mouse Anti-GP6 Recombinant Antibody (clone 12A5); scFv Fragment	WB, ELISA, FuncS	Mouse scFv

CAT	Product Name	Application	Type
HPAB-1711-FY-S(P)	Human Anti-GP6 Recombinant Antibody (clone F1245-4-1); Fab Fragment	ELISA, WB, IHC	Chimeric (mouse/human) Fab
HPAB-1712-FY-S(P)	Human Anti-GP6 Recombinant Antibody (clone F1245-5-1); Fab Fragment	ELISA, WB, IHC	Chimeric (mouse/human) Fab
HPAB-1713-FY-S(P)	Human Anti-GP6 Recombinant Antibody (clone F1245-6-2); Fab Fragment	ELISA, WB, IHC	Chimeric (mouse/human) Fab
HPAB-1714-FY-S(P)	Human Anti-GP6 Recombinant Antibody (clone F1232-7-1); Fab Fragment	ELISA	Human Fab
HPAB-1715-FY-S(P)	Human Anti-GP6 Recombinant Antibody (clone F1232-18-3); Fab Fragment	ELISA	Human Fab

CAT	Product Name	Application	Type
TAB-003CT-S(P)	Anti-Human GPVI Recombinant Antibody scFv Fragment (1C3)	Funcs, ELISA, Inhib, FC	Human antibody
TAB-003CT-F(E)	Anti-Human GPVI Recombinant Antibody Fab Fragment (1C3)	ELISA, Inhibition, FC	Human antibody