Anti-Human GPVI Recombinant Antibody (1C3) (CAT#: TAB-003CT)

Figure 1 1C3 potentiates 10B12 inhibition of collagen- and CRP-XL-induced platelet aggregation.

Platelet-rich plasma was incubated for 5 min with a titration of monomeric 10B12, with (closed circle) or without (open circle) a saturating concentration (20 μg/ml) of monomeric 1C3. 2.0 μg/ml of fibrillar collagen was added and the rate (C) and extent (D) of aggregation measured. The effect of 20 μg/ml of 1C3 alone in each case is apparent on the y-axis (0 μg/ml 10B12). Results are expressed as percentage of platelet aggregation in the absence of scFvs. Points represent 2-8 determinations from experiments performed on platelets from three individual donors.

O'Connor, M. N., Smethurst, P. A., Davies, L. W., Joutsi-Korhonen, L., Onley, D. J., Herr, A. B., ... & Ouwehand, W. H. (2006). Selective blockade of glycoprotein VI clustering on collagen helices. Journal of Biological Chemistry, 281(44), 33505-33510.