Recombinant monoclonal antibody to GPVI. This antibody intended for the prophylaxis and treatment of Thrombosis and other vascular diseases.
Figure 1 1C3 potentiates 10B12 inhibition of collagen- and CRP-XL-induced platelet aggregation.
Platelet-rich plasma was incubated for 5 min with a titration of monomeric 10B12, with (closed circle) or without (open circle) a saturating concentration (20 μg/ml) of monomeric 1C3. 2.0 μg/ml of fibrillar collagen was added and the rate (C) and extent (D) of aggregation measured. The effect of 20 μg/ml of 1C3 alone in each case is apparent on the y-axis (0 μg/ml 10B12). Results are expressed as percentage of platelet aggregation in the absence of scFvs. Points represent 2-8 determinations from experiments performed on platelets from three individual donors.
O'Connor, M. N., Smethurst, P. A., Davies, L. W., Joutsi-Korhonen, L., Onley, D. J., Herr, A. B., ... & Ouwehand, W. H. (2006). Selective blockade of glycoprotein VI clustering on collagen helices. Journal of Biological Chemistry, 281(44), 33505-33510.
Figure 2 Antibody binding curves for GPVI dimer and monomer.
Binding of GPVI dimer to immobilized antibody: m-Fab-F (black closed diamonds), 204-11 Fab (black closed triangles), 204-11 IgG (gray inverted closed triangles), 1G5 (gray closed circles), and 1C3 (gray closed squares) determined by ELISA using HRP-labeled anti-human-Fc antibody.
Jung, S. M., Moroi, M., Soejima, K., Nakagaki, T., Miura, Y., Berndt, M. C., ... & Watson, S. P. (2012). Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. Journal of Biological Chemistry, 287(35), 30000-30013.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1438z | Mouse Anti-GP6 Recombinant Antibody (clone 38C4) | WB, ELISA, IF, IP | Mouse IgG2b, κ |
HPAB-0002-CN | Human Anti-GP6 Recombinant Antibody (HPAB-0002-CN) | FC, WB | Humanized IgG |
HPAB-0003-CN | Human Anti-GP6 Recombinant Antibody (HPAB-0003-CN) | FC, WB | Humanized IgG |
HPAB-0004-CN | Mouse Anti-GP6 Recombinant Antibody (HPAB-0004-CN) | FC, WB | Mouse IgG |
FAMAB-0101JF | Mouse Anti-GP6 Recombinant Antibody (clone 12A5) | WB, ELISA, IHC, FC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-005CT | Mouse Anti-GP6 Recombinant Antibody (TAB-005CT) | WB, ELISA, Block | Mouse IgG1, κ |
TAB-005CT-S(P) | Mouse Anti-GP6 Recombinant Antibody; scFv Fragment (TAB-005CT-S(P)) | WB, ELISA, Block | Mouse scFv |
TAB-005CT-F(E) | Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (TAB-005CT-F(E)) | WB, ELISA, Block | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-003CT-S(P) | Anti-Human GPVI Recombinant Antibody scFv Fragment (1C3) | Funcs, ELISA, Inhib, FC | Human antibody |
TAB-003CT-F(E) | Anti-Human GPVI Recombinant Antibody Fab Fragment (1C3) | ELISA, Inhibition, FC | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1483 | Hi-Affi™ Rabbit Anti-GP6 Recombinant Antibody (clone DS1483AB) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0002-CN-F(E) | Human Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0002-CN-F(E)) | FC, WB | Humanized Fab |
HPAB-0003-CN-F(E) | Human Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0003-CN-F(E)) | FC, WB | Humanized Fab |
HPAB-0004-CN-F(E) | Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0004-CN-F(E)) | FC, WB | Mouse Fab |
HPAB-0133CQ-F(E) | Human Anti-GP6 Recombinant Antibody (clone hGP 5C4); Fab Fragment | ELISA, FC, Inhib, FuncS | Humanized Fab |
FAMAB-0101JF-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone 12A5); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1711-FY-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone F1245-4-1); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
HPAB-1712-FY-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone F1245-5-1); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
HPAB-1713-FY-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone F1245-6-2); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
HPAB-1714-FY-F(E) | Human Anti-GP6 Recombinant Antibody (clone F1232-7-1); scFv Fragment | ELISA | Human scFv |
FAMAB-0289JF-S(P) | Human Anti-GP6 Recombinant Antibody (clone 1C3); scFv Fragment | FC, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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