The anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibody target mGluR2 which contribute to the fine-tuning of synaptic efficacy. The llama-derived anti-mGluR2 single domain antibody act as a positive allosteric modulator and are able to stabilized the active state of mGluR2. Therefore, the anti-mGluR2 single domain antibody can be useful in the treatment of schizophrenia, epilepsy, addiction/drug dependence, Parkinson's disease, pain, sleep disorders and Huntington's disease.
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