Recombinant Human Anti-H1N1 Antibody (del2D1) (CAT#: PABL-110)

Recombinant Human Antibody (del2D1) is capable of binding to H1N1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-H1N1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-H1N1 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.


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Figure 2 Therapeutic efficacy of 1918 HA-specific MAbs against disease caused by the 1918 A(H1N1) virus in mice.

Figure 2 Therapeutic efficacy of 1918 HA-specific MAbs against disease caused by the 1918 A(H1N1) virus in mice.

Mice were inoculated on day 0 and treated on day 1 with the indicated antibody and dose. In each group, six mice were monitored every other day for weight (A) and survival (B).

Krause, J. C., Ekiert, D. C., Tumpey, T. M., Smith, P. B., Wilson, I. A., & Crowe, J. E. (2011). An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody. MBio, 2(1), e00345-10.


Specifications

  • Immunogen
  • Influenza A virus subtype H1N1
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG
  • Specificity
  • Tested positive against native IAV H1N1
  • Species Reactivity
  • IAV
  • Clone
  • del2D1
  • Applications
  • Can be useful in applications such as: Western blot; Enzyme-linked Immunosorbent Assay; Functional Study

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Target

  • Alternative Names
  • Influenza A virus subtype H1N1; H1N1; Influenza A (H1N1) virus; influenza A virus

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone del2D1"

See other products for "H1N1"

Single-domain Antibody

CAT Product Name Application Type
NABG-074 Recombinant Anti-H1N1 VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4205 Hi-Affi™ Recombinant Rabbit Anti-H1N1 Monoclonal Antibody (SI283DS) WB, ELISA, FC, IP IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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