Anti-HCMV gB Recombinant Antibody (4H9) (CAT#: MRO-1042LC)

This product is a full length recombinant human anti-Human Cytomegalovirus monoclonal antibody. 4H9 specifically binds to envelope glycoprotein gB associated with HCMV and can be potentially used in the research and diagnosis of Human Cytomegalovirus infection. It can neutralize hCMV infection.


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Block

Figure 1 Immunofluorescent staining of VR1814-infected ARPE-19 epithelial cells at 96 h p.i. HCMV fluorescent nuclei (p72) are shown in green, while Evans blue counterstaining is shown in red.

Figure 1 Immunofluorescent staining of VR1814-infected ARPE-19 epithelial cells at 96 h p.i. HCMV fluorescent nuclei (p72) are shown in green, while Evans blue counterstaining is shown in red.

MAbs to the pentamer complex and its pUL128L components completely blocked syncytium formation (SF) at the higher concentration tested (10 µg/ml), unlike mAbs to gO, gH, or gB, which only partially inhibited SF.

The pentameric complex of human Cytomegalovirus: cell tropism, virus dissemination, immune response and vaccine development

FC

Figure 2 shows cross-competition experiments in which HEK293T cells transfected with hCMV gB gene were first incubated with an unlabeled competitor antibody followed by staining with a biotinylated anti-gH or anti-gB antibody.

Figure 2 shows cross-competition experiments in which HEK293T cells transfected with hCMV gB gene were first incubated with an unlabeled competitor antibody followed by staining with a biotinylated anti-gH or anti-gB antibody.


Specifications

  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human Cytomegalovirus
  • Clone
  • 4H9
  • Applications
  • ELISA, Block, FC
  • Related Disease
  • Human Cytomegalovirus infection

Applications

  • Application Notes
  • The HCMV gB antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Blocking, Flow Cytometry.

Target

  • Alternative Names
  • Human Cytomegalovirus; HCMV; Human Cytomegalovirus envelope glycoprotein B; HCMV gB

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 4H9"

See other products for "HCMV GB"

Humanized Antibody

Human Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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