Anti-HCMV gB Recombinant Antibody ( ITC52) (CAT#: MRO-1051LC)
This product is a recombinant human anti-Human Cytomegalovirus monoclonal antibody (ITC52). ITC52 specifically binds to envelope glycoprotein gB associated with HCMV and can be potentially used in the treatment and diagnosis of human Cytomegalovirus infection.
Specific Inquiry
IB
Figure 1. Reactivity of human MAbs ITC39 and ITC48 with prokaryotically expressed fusion proteins containing mutations in AD-1.
Speckner, A., Glykofrydes, D., Ohlin, M., & Mach, M. (1999). Antigenic domain 1 of human cytomegalovirus glycoprotein B induces a multitude of different antibodies which, when combined, results in incomplete virus neutralization. Journal of general virology, 80(8), 2183-2191.
Neut
Figure 2. Neutralizing activity of monoclonal and polyclonal AD-1-specific antibodies.
Speckner, A., Glykofrydes, D., Ohlin, M., & Mach, M. (1999). Antigenic domain 1 of human cytomegalovirus glycoprotein B induces a multitude of different antibodies which, when combined, results in incomplete virus neutralization. Journal of general virology, 80(8), 2183-2191.
WB
Figure 3. Determination of the molecular weights of native antigen recognized by monoclonal antibodies ITC33 (lanes a), ITC34 (lane b), ITC39 (lane c), ITC48 (lane d), ITC52 (lane e), ITC63B (lane f), ITC88 (lane g), and mouse anti-gp58 antibody 27-287 (lane h) by SDS-PAGE and Western blot.
Ohlin, M., Sundqvist, V. A., Mach, M. I. C. H. A. E. L., Wahren, B., & Borrebaeck, C. A. (1993). Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. Journal of virology, 67(2), 703-710.
FC
Figure 4. Anti-AD-1 (ITC33, ITC39, ITC48, ITC52, and ITC63B) monoclonal antibodies (mAbs), anti-AD-2 (ITC88) mAbs, or a polyclonal anti-HCMV gB serum were used as potential competitors of the HCMV gB binding to immature DC-SIGN+ monocyte-derived dendritic cells (MDDCs). Binding of HCMV gB was assessed by flow cytometry.
Chéneau, C., Coulon, F., Porkolab, V., Fieschi, F., Laurant, S., Razanajaona-Doll, D., ... & Halary, F. (2018). Fine Mapping the Interaction Between Dendritic Cell-Specific Intercellular Adhesion Molecule (ICAM)-3-Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B. The Journal of infectious diseases, 218(3), 490-503.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human Cytomegalovirus
- Clone
- ITC52
- Applications
- IB, Neut, WB, FC
- Related Disease
- Human Cytomegalovirus infection
Applications
- Application Notes
- The ITC52 antibody has been reported in applications of IB, Neut, WB, FC.
It's recommended that the optimal antibody concentration, dilution, incubation time etc. are best to be carefully titrated in specific assays. For details, refer to Published Data.
Target
- Alternative Names
- Human Cytomegalovirus; HCMV; Human Cytomegalovirus envelope glycoprotein B; HCMV gB
- Gene ID
- 3077424
- UniProt ID
- F5HB53
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone ITC52"
See other products for "HCMV GB"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-443-S(P) | Recombinant Anti-HCMV GB Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| MHH-443-S(P) | Recombinant Human Anti-HCMV GB Antibody scFv Fragment | WB, FC, FuncS | scFv |
| FAMAB-0173CQ-S(P) | Recombinant Mouse Anti-HCMV gB Antibody scFv Fragment (7-17) | ELISA, Neut | Mouse scFv |
| HPAB-0639-CN-S(P) | Recombinant Human Anti-HCMV gB Antibody scFv Fragment (2F10) | ELISA, Neut | Human scFv |
| FAMAB-0145JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone SM1-6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-443 | Recombinant Human Anti-HCMV GB Antibody | FC, Neut, Funcs | IgG |
| FAMAB-0173CQ | Recombinant Mouse Anti-HCMV gB Antibody (7-17) | ELISA, Neut | Mouse IgG3, κ |
| FAMAB-0142JF | Human Anti-HCMV gB Recombinant Antibody (clone SM10) | WB, ELISA, Neut | Human IgG3, κ |
| FAMAB-0143JF | Human Anti-HCMV gB Recombinant Antibody (clone 1G2) | WB, FC, IHC | Human IgG3, λ |
| FAMAB-0144JF | Human Anti-HCMV gB Recombinant Antibody (clone 2C2) | WB, Neut, IHC | Human IgG1, κ |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1032LC | Anti-HCMV gB Recombinant Antibody (TI-23) | ELISA | Humanized antibody |
| MRO-1032LC-S(P) | Anti-HCMV gB Recombinant Antibody scFv Fragment (TI-23) | ELISA | Humanized antibody |
| MRO-1032LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (TI-23) | ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1033LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C1) | ELISA | Human antibody |
| MRO-1034LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C3) | ELISA | Human antibody |
| MRO-1035LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C4) | ELISA | Human antibody |
| MRO-1036LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C7) | ELISA | Human antibody |
| MRO-1037LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C23) | ELISA | Human antibody |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1438LC | Recombinant Human Anti-HCMV gB Antibody (MAb C23) | WB | IgG1 |
| EPAF-1497LC | Recombinant Mouse Anti-HCMV gB Antibody (CH28-2) | ELISA |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0639-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2F10) | ELISA, Neut | Human Fab |
| HPAB-0640-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2M16) | ELISA, Neut | Human Fab |
| HPAB-0641-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (2N9) | ELISA, Neut | Human Fab |
| HPAB-0642-CN-F(E) | Recombinant Human Anti-HCMV gB Antibody Fab Fragment (4P12) | ELISA, Neut | Human Fab |
| FAMAB-0143JF-F(E) | Human Anti-HCMV gB Recombinant Antibody (clone 1G2); Fab Fragment | WB, ELISA, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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