Recombinant Mouse Anti-HEV Capsid protein Antibody (8G12) (CAT#: PABL-129)
Recombinant Mouse Antibody (8G12) is capable of binding to HEV Capsid protein, expressed in Chinese Hamster Ovary cells (CHO). It equally recognizes all four genotypes of HEV, with ∼ 2.53-3.45 nM binding affinity. The mAb 8G12 has a protective, neutralizing capacity, which can significantly block virus infection in host cells.
Specific Inquiry
Figure 2 (C-D) Sedimentation velocity (SV) was utilized to detect the mAb 8G12 binding of E2HEV-1 and E2HEV-4. The c(s) profile of E2HEV-1/E2HEV-4 and its mutants, mAb 8G12 alone, and the antigen-antibody mixture are denoted as black, red and cyan solid curves, respectively. The molar ratio of E2HEV-1/E2HEV-4 or its mutant versus mAb 8G12 was 5:1, so that the antigen was in surplus.
Figure 3 (A, C) The mutants and wild-type p239 (A, genotype 1; C, genotype 4) were subjected to non-reducing SDS-PAGE and western blotting with the neutralizing mAb 8G12 to study the effects of these mutations on p239:8G12.
Figure 4 (B, D) Interaction of the mutants and wild-type p239 (B, genotype 1; D, genotype 4) against mAb 8G12 was tested by enzyme-linked immunosorbent assay and EC50 was calculated by sigmoid trend fitting.
Specifications
- Immunogen
- Hepatitis E virus Capsid protein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native HEV Capsid protein
- Species Reactivity
- HEV
- Clone
- 8G12
- Applications
- ELISA, Neut, FuncS, WB
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody was validated for WB and ELISA. For details, refer to published data.
Target
- Alternative Names
- Capsid protein; HEV Capsid protein; Capsid; Hepatitis E Virus; HEV
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv Antibody Products
Fab Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-129 | Recombinant Mouse Anti-HEV Capsid protein Antibody scFv Fragment (8G12) | ELISA, Neut, FuncS | scFv |
| PFBC-216 | Recombinant Mouse Anti-MNV-1 Capsid protein Antibody Fab Fragment (mAb6.2) | Neut | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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