Human Anti-HIV-1 Env Recombinant Antibody (clone 9H+3L) (CAT#: PABL-143)
Recombinant Human Antibody (9H+3L) is capable of binding to HIV-1 env, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 env mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 env mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 Neutralization assays on JR-FL glycan mutants indicate binding of inferred intermediate antibodies to both N301 and N332 on HIV-1 Env.
(A) Neutralization curves of inferred intermediate antibodies on wild-type JR-FL virus (B) JR-FL N301A mutant virus, and (C) JR-FL N332A mutant virus. (D) Neutralization curves of 3H+3L and (E) PGT121 on wild-type JR-FL virus compared to single and double glycan mutant viruses. (F) Neutralization curves of PGT121 on wild-type 92BR020 virus compared to single and double glycan mutant viruses.
Sok, D., Laserson, U., Laserson, J., Liu, Y., Vigneault, F., Julien, J. P.,... & Mahan, A. (2013). The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS pathogens,9(11), e1003754.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Species Reactivity
- HIV-1
- Clone
- 9H+3L
- Applications
- WB, ELISA, IF, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Neut. For details, refer to published data.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160; precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-474 | Recombinant Anti-HIV-1 Env Antibody | ELISA, WB, IF, FuncS | IgG |
| MRO-2742CQ | Human Anti-HIV-1 Env Recombinant Antibody (clone 10.9D) | ELISA | Human IgG |
| MRO-2743CQ | Human Anti-HIV-1 Env Recombinant Antibody (clone 6.1C) | ELISA | Human IgG |
| MRO-2744CQ | Human Anti-HIV-1 Env Recombinant Antibody (clone 8.9D) | ELISA, Neut | Human IgG |
| MRO-2745CQ | Human Anti-HIV-1 Env Recombinant Antibody (MRO-2745CQ) | Neut | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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