Recombinant Anti-HIV-1 Vpr Intrabody [(D-Arg)9] (CAT#: IAB-B054(A))
Recombinant anti-HIV-1 Vpr intrabody linked to (D-Arg)9 works within cells and specifically reacts with HIV-1 Vpr, expressed in CHO cells. It is able and specifically reacts with the HIV-1 regulatory Vpr protein in the cytoplasm of eukaryotic cells, leading to its delocalization from the nucleus to the cytoplasm.
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Custom Production
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Specifications
- Immunogen
- human papillomavirus Vpr
- Host Species
- llama
- Type
- vhh-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- HIV-1
- Applications
- Formats of immunological tests: Western blot; Immunocytochemistry; Functional studies
Product Property
- Purity
- 95% by HPLC
- Storage
- 4°C or -20°C, avoid repeated freezing and thawing.
Target
- Alternative Names
- HIV-1 Vpr; human papillomavirus Vpr
- Gene ID
- 155807
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Intrabody Products
MHC Tetramer Products for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B054(G) | Recombinant Anti-HIV-1 Vpr Intrabody [+36 GFP] | ICC, Neut, FuncS | vhh-(+36GFP) |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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