Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 58.2) (CAT#: PABW-060)
Recombinant Mouse Antibody (58. 2) is capable of binding to HIV-1 gp120, expressed in mammalian cells. This antibody raised against peptides with V3 sequences can neutralize laboratory-adapted strains of the virus and inhibit syncytia formation.
Specific Inquiry
Figure 1 Effect of thrombin cleavage on binding of V3 MAbs to MN gp120.
MN gp120, captured by antibody D7324, was incubated for 1 h with (F) or without (E) thrombin before removal of the enzyme by washing. MAbs (as indicated in each panel) were then added at the concentrations indicated, and the amount of bound MAb was detected.
Moore, J. P., Trkola, A., Korber, B., Boots, L. J., Kessler, J. A., McCutchan, F. E., ... & Conley, A. J. (1995). A human monoclonal antibody to a complex epitope in the V3 region of gp120 of human immunodeficiency virus type 1 has broad reactivity within and outside clade B. Journal of virology, 69(1), 122-130.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Tested positive against HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- 58.2
- Applications
- Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp120 antibody has been reported in applications of ELISA.
ELISA: Briefly, serial dilutions of freshly prepared, low-passage primary virus stocks were mixed with MAb (100 mg/ml), human HIV-1-positive serum (1:50 dilution), or media and incubated for 1 h at 37°C. Titers of the virus on PBMC were determined, and virus replication was assessed after 7 days of culture by p24 antigen-capture enzyme-linked immunosorbent assay.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
| MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
| MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
| MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 83.1) | Neut | Mouse IgG1 |
| PABZ-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 0.5β) | Neut | Mouse IgG |
| PABC-062 | Recombinant Human Anti-HIV-1 gp120 Antibody (2G12) | Neut, ELISA | IgG |
| PABC-063 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 47e) | Neut | Human IgG |
| PABZ-063 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 48D) | ELISA, FuncS, IP | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-160 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105); scFv Fragment | FC, Neut | Human scFv |
| PSBW-178 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b12); scFv Fragment | Neut, ELISA | Human scFv |
| MRO-3081CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH276); Fab Fragment | Neut | Human Fab |
| MRO-3082CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH374); Fab Fragment | Neut | Human Fab |
| MRO-3083CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH375); Fab Fragment | Neut | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
| MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
| MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
| MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
| MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
| MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
| MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-041LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (D59/A2) | ELISA | Mouse antibody |
| MRO-042LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (F58/H3) | ELISA | Mouse antibody |
| MRO-043LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P1/D12) | ELISA | Mouse antibody |
| MRO-044LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P4/D10) | ELISA | Mouse antibody |
| MRO-045LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (A47/B1) | ELISA | Mouse antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3532CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 6A); scFv Fragment | ELISA | Humanized scFv |
| MRO-3533CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 8A); scFv Fragment | ELISA | Humanized scFv |
| MRO-3534CQ-S(P) | Monkey Anti-HIV-1 gp120 Recombinant Antibody (clone 1.8E); scFv Fragment | Neut | Monkey scFv |
| MRO-3535CQ-S(P) | Monkey Anti-HIV-1 gp120 Recombinant Antibody (clone 2.10A); scFv Fragment | Neut | Monkey scFv |
| MRO-3649CQ-S(P) | Rat Anti-HIV-1 gp120 Recombinant Antibody (clone 62c); scFv Fragment | ELISA | Rat scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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