Recombinant Human Anti-HIV-1 gp120 Antibody (2G12) (CAT#: PABC-062)

Recombinant Human Antibody (2G12) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp120 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This neutralizing human antibody recognizes terminal Man 1-2Man–linked moieties, contributed by oligomannose-type sugars that form a cluster on the silent face of gp120.

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Neut

Figure 1 Human Anti-HIV-1 gp120 Antibody (2G12) in Neut.

Figure 1 Human Anti-HIV-1 gp120 Antibody (2G12) in Neut.

Inhibition of the binding of 2G12 mAb to HIV-1-infected MT-4 cells in the presence of GNA, HHA and CV-N. MT-4 cells infected with HIV-1 strains IIIB (left panel), MN (middle panel) and NDK (right panel), were incubated with 2G12 mAb in the absence (red histograms) or presence of different concentrations of GNA (green histograms), HHA (orange histograms) and CV-N (light blue). The dark blue histograms show the background fluorescence. The mean fluorescence intensity (MFI) values are indicated in each histogram.

Schols, D. (2010). Microvirin, a novel (1, 2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile. proteins, 1, 3.


Specifications

  • Immunogen
  • HIV-1 gp160; envelope glycoprotein
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG
  • Specificity
  • Tested positive against native HIV-1 gp120
  • Species Reactivity
  • HIV-1
  • Clone
  • 2G12
  • Applications
  • Can be useful in applications such as: Neutralization, Enzyme-linked Immunosorbent Assay

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Target

  • Alternative Names
  • ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "HIV-1 gp120"

Recombinant Antibody

Chimeric Antibody

CAT Product Name Application Type
MRO-135LC Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) ELISA, WB, Neut Chimeric antibody (mouse/human)
MRO-135LC-S(P) Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) ELISA, WB Chimeric antibody (mouse/human)
MRO-135LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) ELISA, WB Chimeric antibody (mouse/human)

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4220 Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) WB, ELISA Rabbit IgG

Humanized Antibody

CAT Product Name Application Type
PABX-101-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment WB, ELISA, FuncS Human scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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