Recombinant Human Antibody (E51) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp120 mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 In vitro neutralization by combinations of CD4bs antibodies with CD4i antibodies.
(A) HIV-1 isolates 89.6, ADA, and SG3 were preincubated for 1 h with a fixed total concentration (0.3 ug/ml for 89.6 and ADA and 0.005 g/ml for SG3) but various ratios of VRC01-E51 mixtures. TZM-bl cells were then added and incubated for 48 h. Infection was measured by the percent luciferase expression in the absence of inhibitor. (B) Experiment similar to that for panel A except that the indicated isolates were preincubated for 1 h with a fixed total concentration (0.3 ug/ml for 89.6 and ADA and 1.0 ug/ml for SA32) but various ratios of VRC01-412d mixtures. Error bars represent standard error of mean (SEM).
Gardner, M. R., Fellinger, C. H., Prasad, N. R., Zhou, A. S., Kondur, H. R., Joshi, V. R., ... & Farzan, M. (2016). CD4-induced antibodies promote association of the HIV-1 envelope glycoprotein with CD4-binding site antibodies. Journal of virology, JVI-00803.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135); scFv Fragment | ELISA, Neut | Human scFv |
PSBL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PFBZ-209 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L3); Fab Fragment | Neut | Human Fab |
PFBW-160 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105); Fab Fragment | FC, Neut | Human Fab |
PFBW-178 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b12); Fab Fragment | Neut, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-164 | Human Anti-HIV-1 gp120 Recombinant Antibody; scFv Fragment (PSBZ-164) | Neut | Human scFv |
PSBZ-165 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone GL-VRC01); scFv Fragment | Neut | Human scFv |
PSBZ-209 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L3); scFv Fragment | Neut | Human scFv |
PSBZ-210 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L1); scFv Fragment | Neut | Human scFv |
FAMAB-0177CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone BAT123); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-162LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-162LC) | ELISA, FC, Neut, SPR | Human IgG1, κ |
MRO-164LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-164LC) | ELISA | Human IgG1, κ |
MRO-165LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-165LC) | ELISA | Human IgG1, κ |
MRO-166LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-166LC) | ELISA, FuncS, FC, Neut | Human IgG1, κ |
MRO-167LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-167LC) | ELISA | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (D59/A2) | ELISA | Mouse antibody |
MRO-042LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (F58/H3) | ELISA | Mouse antibody |
MRO-043LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P1/D12) | ELISA | Mouse antibody |
MRO-044LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P4/D10) | ELISA | Mouse antibody |
MRO-045LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-4363CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (1B5 (VHH 1B5)) | Neut | Camelid VHH |
MRO-4364CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (1C2 (VHH 1C2)) | Neut | Camelid VHH |
MRO-4365CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (1E1 (VHH 1E1)) | Neut | Camelid VHH |
MRO-4366CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (1E2 (VHH 1E2)) | Neut | Camelid VHH |
MRO-4367CQ | Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (1F10 (VHH 1F10)) | Neut | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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