Recombinant Mouse Antibody (G3-519) is capable of binding to HIV-1 gp120, expressed in mammalian cells. G3-519,recognizes an epitope from the fourth conserved region (C4) of gp120 that plays an important role in interaction with CD4. It neutralizes various HIV-1 strains in vitro.
Figure 1 ELISA binding curves of select anti-gp120 Abs against full-length and loop-deleted constructs of gp140JR-FL.
Full-length (diamonds), V1-deleted (squares), V2-deleted (triangles), and V3-deleted (x) gp140JR-FL were captured via the C-terminal region of gp120 with the sheep Ab D7324 and probed with pooled HIVIG, 2G12, Fab AH48, G3-4, G3-519, G3-42, G3-299, and 4KG5. The detection reagents were ABTS for 4KG5 and AP staining solution for all other Abs.
Zwick, M. B., Kelleher, R., Jensen, R., Labrijn, A. F., Wang, M., Quinnan, G. V., ... & Burton, D. R. (2003). A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12. Journal of virology, 77(12), 6965-6978.
Figure 2 Selective inhibition of the alternative complement activity in human whole blood by MAb 166-32 at 18 μg/mL in the extra-corporeal circulation studies before recirculation.
MAb 166-32 did not inhibit the classical complement activity of the human plasma in the circuits. The negative control MAb G3-519 had no effects on either the alternative or the classical complement activity. Values are given as means ± SD from 5 paired experiments of the test and control circuits. Percentage of hemolysis was defined as indicat-ed in the text. P values were determined by means of paired t tests between MAb 166–32– and MAb G3–519–treated circuits in the alternative complement hemolytic assays.
Fung, M., Loubser, P. G., Ündar, A., Mueller, M., Sun, C., Sun, W. N., ... & Fraser Jr, C. D. (2001). Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits. The Journal of Thoracic and Cardiovascular Surgery, 122(1), 113-122.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-380 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06); scFv Fragment | Neut, FuncS | Human scFv |
PFBZ-164 | Human Anti-HIV-1 gp120 Recombinant Antibody; Fab Fragment (PFBZ-164) | Neut | Human Fab |
PFBZ-165 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone GL-VRC01); Fab Fragment | Neut | Human Fab |
FAMAB-0178CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone C beta 1); scFv Fragment | WB, Neut | Mouse scFv |
MRO-3203CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone N10-i6.1); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABW-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 58.2) | Neut | Mouse IgG1 |
PABC-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 83.1) | Neut | Mouse IgG1 |
PABZ-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 0.5β) | Neut | Mouse IgG |
PABC-062 | Recombinant Human Anti-HIV-1 gp120 Antibody (2G12) | Neut, ELISA | IgG |
PABC-063 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 47e) | Neut | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-160 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105); scFv Fragment | FC, Neut | Human scFv |
PSBW-178 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b12); scFv Fragment | Neut, ELISA | Human scFv |
MRO-2957CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 10-346); Fab Fragment | Neut | Human Fab |
MRO-2958CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 10-390); Fab Fragment | Neut | Human Fab |
MRO-2959CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 10-415); Fab Fragment | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-132LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT123) | ELISA, WB, IF, Neut | Mouse antibody |
MRO-133LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT267) | ELISA, WB, Neut | Mouse antibody |
MRO-134LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT085) | ELISA, WB, IF, Neut | Mouse antibody |
MRO-150LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-4) | ELISA, Inhib, FC, Neut, RIPA, DB, IP | Mouse antibody |
MRO-152LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-136) | Neut, ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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