Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247) (CAT#: PABL-546)
Recombinant Humanized Antibody (KD-247) is capable of binding to HIV-1 gp120, expressed in mammalian cells. This antibody can neutralize a broad spectrum of CCR5- and CXCR4-tropic viruses and HIV-1 quasi-species.
Specific Inquiry
FuncS
Figure 1 The gp120 mutation profile of HIV-1BaL evasion variants from KD-247 in vitro.
The ratio of the PNGS insertion in the V2 region and mutations in the C2 and V3 regions in gp120 of HIV-1BaL variants were plotted for each passage. The y-axis indicates the percentage of PNGS insertions or mutations in the tested clones and the x-axis shows the concentration of KD-247 (μg/ml).
Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., & Matsushita, S. (2010). Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2. Journal of General Virology, 91(5), 1335-1345.
Inhib
Figure 2 Sensitivities of HIV-1 strains pseudo-typed with recombinant HIV-1BaLenv genes to KD-247 inhibitor.
KD-247 was pre-incubated with 300 TCID50 of each HIV-1BaL pseudotype virus for 30 min, then added to TZM-bl target cells. Inhibitory effects were determined by measuring β-galactosidase activity on day 2 of culture.
Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., & Matsushita, S. (2010). Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2. Journal of General Virology, 91(5), 1335-1345.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Tested positive against HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- KD-247
- Applications
- FuncS, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition and Function Assay.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135); scFv Fragment | ELISA, Neut | Human scFv |
| PSBL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03); scFv Fragment | WB, ELISA, Neut, FuncS | Human scFv |
| PSBL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31); scFv Fragment | WB, ELISA, Neut, FuncS | Human scFv |
| PSBL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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