Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247) (CAT#: PABL-546)
Recombinant Humanized Antibody (KD-247) is capable of binding to HIV-1 gp120, expressed in mammalian cells. This antibody can neutralize a broad spectrum of CCR5- and CXCR4-tropic viruses and HIV-1 quasi-species.
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FuncS
Figure 1 The gp120 mutation profile of HIV-1BaL evasion variants from KD-247 in vitro.
The ratio of the PNGS insertion in the V2 region and mutations in the C2 and V3 regions in gp120 of HIV-1BaL variants were plotted for each passage. The y-axis indicates the percentage of PNGS insertions or mutations in the tested clones and the x-axis shows the concentration of KD-247 (μg/ml).
Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., & Matsushita, S. (2010). Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2. Journal of General Virology, 91(5), 1335-1345.
Inhib
Figure 2 Sensitivities of HIV-1 strains pseudo-typed with recombinant HIV-1BaLenv genes to KD-247 inhibitor.
KD-247 was pre-incubated with 300 TCID50 of each HIV-1BaL pseudotype virus for 30 min, then added to TZM-bl target cells. Inhibitory effects were determined by measuring β-galactosidase activity on day 2 of culture.
Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., & Matsushita, S. (2010). Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2. Journal of General Virology, 91(5), 1335-1345.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Tested positive against HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- KD-247
- Applications
- FuncS, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Inhibition and Function Assay.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Humanized Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
| PABL-161 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 2.2c) | WB, ELISA, FuncS | Human IgG1 |
| PABL-163 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3bnc117) | Neut, ELISA, FuncS | Human IgG |
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