Human Anti-HIV-1 gp120 Recombinant Antibody (clone KD-247) (CAT#: PABL-546)

Recombinant Humanized Antibody (KD-247) is capable of binding to HIV-1 gp120, expressed in mammalian cells. This antibody can neutralize a broad spectrum of CCR5- and CXCR4-tropic viruses and HIV-1 quasi-species.

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FuncS

Figure 1 The gp120 mutation profile of HIV-1BaL evasion variants from KD-247 in vitro.

The ratio of the PNGS insertion in the V2 region and mutations in the C2 and V3 regions in gp120 of HIV-1BaL variants were plotted for each passage. The y-axis indicates the percentage of PNGS insertions or mutations in the tested clones and the x-axis shows the concentration of KD-247 (μg/ml).

Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., & Matsushita, S. (2010). Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2. Journal of General Virology, 91(5), 1335-1345.

Inhib

Figure 2 Sensitivities of HIV-1 strains pseudo-typed with recombinant HIV-1BaLenv genes to KD-247 inhibitor.

KD-247 was pre-incubated with 300 TCID50 of each HIV-1BaL pseudotype virus for 30 min, then added to TZM-bl target cells. Inhibitory effects were determined by measuring β-galactosidase activity on day 2 of culture.

Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., & Matsushita, S. (2010). Human immunodeficiency virus type 1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2. Journal of General Virology, 91(5), 1335-1345.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized IgG
  • Specificity
  • Tested positive against HIV-1 gp120
  • Species Reactivity
  • HIV-1
  • Clone
  • KD-247
  • Applications
  • FuncS, Inhib

Applications

  • Application Notes
  • This antibody has been reported for use in Inhibition and Function Assay.

Target

  • Alternative Names
  • ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Single-domain Antibody

CAT Product Name Application Type
NABG-082 Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH
MRO-028LC-VHH Anti-HIV-1 gp120 Recombinant Antibody (L91C2) ELISA Single domain antibody
MRO-029LC-VHH Anti-HIV-1 gp120 Recombinant Antibody (L91F10) ELISA Single domain antibody
MRO-030LC-VHH Anti-HIV-1 gp120 Recombinant Antibody (L91E1) ELISA Single domain antibody
MRO-031LC-VHH Anti-HIV-1 gp120 Recombinant Antibody (L91B5) ELISA Single domain antibody

Recombinant Antibody

CAT Product Name Application Type
PABL-135 Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) ELISA, Neut Human IgG
PABL-142 Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) Neut, WB, ELISA, FuncS Human IgG
PABL-155 Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) WB, ELISA, Neut, FuncS Human IgG
PABL-156 Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) WB, ELISA, Neut, FuncS Human IgG
PABL-160 Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) WB, ELISA, FuncS Mouse IgG1, κ

Fab Fragment Antibody

CAT Product Name Application Type
PSBZ-164 Human Anti-HIV-1 gp120 Recombinant Antibody; scFv Fragment (PSBZ-164) Neut Human scFv
PSBZ-165 Human Anti-HIV-1 gp120 Recombinant Antibody (clone GL-VRC01); scFv Fragment Neut Human scFv
PSBW-160 Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105); scFv Fragment FC, Neut Human scFv
PSBW-178 Human Anti-HIV-1 gp120 Recombinant Antibody (clone b12); scFv Fragment Neut, ELISA Human scFv
MRO-3015CQ-F(E) Human Anti-HIV-1 gp120 Recombinant Antibody (clone 212A (2.12A)); Fab Fragment ELISA Human Fab

Chimeric Antibody

CAT Product Name Application Type
MRO-135LC Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) ELISA, WB, Neut Chimeric antibody (mouse/human)
MRO-135LC-S(P) Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) ELISA, WB Chimeric antibody (mouse/human)
MRO-135LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) ELISA, WB Chimeric antibody (mouse/human)

Human Antibody

CAT Product Name Application Type
MRO-162LC Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-162LC) ELISA, FC, Neut, SPR Human IgG1, κ
MRO-164LC Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-164LC) ELISA Human IgG1, κ
MRO-165LC Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-165LC) ELISA Human IgG1, κ
MRO-166LC Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-166LC) ELISA, FuncS, FC, Neut Human IgG1, κ
MRO-167LC Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-167LC) ELISA Human IgG1, κ

Mouse Antibody

CAT Product Name Application Type
MRO-041LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (D59/A2) ELISA Mouse antibody
MRO-042LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (F58/H3) ELISA Mouse antibody
MRO-043LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P1/D12) ELISA Mouse antibody
MRO-044LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P4/D10) ELISA Mouse antibody
MRO-045LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (A47/B1) ELISA Mouse antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4220 Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) WB, ELISA Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
MRO-3341CQ-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC13 (44-VRC13.01)); scFv Fragment Neut Human scFv
MRO-3342CQ-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC16 (C38-VRC16.01)); scFv Fragment Neut Human scFv
MRO-3343CQ-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC22); scFv Fragment Neut Human scFv
MRO-3344CQ-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC23b); scFv Fragment Neut Human scFv
MRO-3345CQ-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC24); scFv Fragment Neut Human scFv

Humanized Antibody

CAT Product Name Application Type
PABX-101-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment WB, ELISA, FuncS Human scFv

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For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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