Recombinant Human Antibody (VRC18.02) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp160 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp160 mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody neutralized 67% of circulating HIV-1 isolates
Figure 1 Flow cytometric identification of RSC3-reactive IgG+ B cells from donor 44, C38 and Z258. Gating and percentage of antigen-specific (RSC3+, ΔRSC3-) memory B cells (CD19+, CD20+, IgG+) are indicated. Neighbor-joining trees display the protein distance of gp160 sequences from 176 gp160 sequences. A scale bar denotes 5% distance in amino acid sequence. Tree branches are colored by the neutralization potencies of VRC13.01, VRC16.01, VRC18.02 and VRC27.01 against each virus.
Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A.,... & Ernandes, M. J. (2015). Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell, 161(6), 1280-1292.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01) | FC, Neut | Human IgG |
PABL-555 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) | FC, Neut | Human IgG |
PABL-556 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-556) | Neut | Human IgG |
PABL-557 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) | FC, Neut | Human IgG |
PABW-163 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 268-D) | ELISA, Neut | Human IgG1,λ |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
MRO-3754CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone RV110026); Fab Fragment | ELISA, WB | Human Fab |
MRO-3755CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 989-D); Fab Fragment | FC | Human Fab |
MRO-3756CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone m66S28LCH); Fab Fragment | Neut | Human Fab |
MRO-3757CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone m66G30LCK); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-075LC | Anti-HIV-1 gp160 Recombinant Antibody (24G3) | WB, ELISA | Human antibody |
MRO-080LC | Anti-HIV-1 gp160 Recombinant Antibody (81C7) | ELISA | Human antibody |
MRO-091LC | Anti-HIV-1 gp160 Recombinant Antibody (MAb CL1) | ELISA | Human antibody |
MRO-100LC | Anti-HIV-1 gp160 Recombinant Antibody (N7019b) | ELISA | Human antibody |
MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
MRO-089LC | Anti-HIV-1 gp160 Recombinant Antibody (2H8) | ELISA | Mouse antibody |
MRO-086LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1C1) | ELISA | Mouse antibody |
MRO-087LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1H9) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-4032CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone Aw); scFv Fragment | Neut | Rat scFv |
MRO-4033CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone Bw); scFv Fragment | Neut | Rat scFv |
MRO-4034CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone Dv); scFv Fragment | Neut | Rat scFv |
MRO-4035CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone Fv); scFv Fragment | Neut | Rat scFv |
MRO-4036CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone Gv); scFv Fragment | Neut | Rat scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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