Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) (CAT#: PABL-555)

Recombinant Human Antibody (C38-VRC18.02) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp160 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp160 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody neutralized 67% of HIV-1 strains.


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Figure 1 Flow cytometric identification of RSC3-reactive IgG+ B cells from a donor (donor C38).

Figure 1 Flow cytometric identification of RSC3-reactive IgG+ B cells from a donor (donor C38).

Gating and percentage of antigen-specific(RSC3+, ΔRSC3-) memory B cells (CD19+, CD20+, IgG+) are indicated. Sorted cells are in light gray while VRC27.01 and its respective clonal relatives are highlighted by colored dots.

Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A., ... & Ernandes, M. J. (2015). Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell, 161(6), 1280-1292.


Specifications

  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Tested positive against HIV-1 gp160
  • Species Reactivity
  • HIV-1
  • Clone
  • C38-VRC18.02
  • Applications
  • FC Assay-dependent
    Neut Assay-dependent

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Assay-dependent

Target

  • Alternative Names
  • ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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