Human Anti-HIV-1 gp160 Recombinant Antibody (clone 268-D) (CAT#: PABW-163)
Recombinant Human Antibody (268-D) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. As V3 residues Lys305, His308 and Arg315 are among the most variable residues in the V3 crown, specificity for their side chains makes mAb 268-D highly strain specific.
Specific Inquiry
Figure 1 QES mutations at EnvBaL subunit interfaces are insufficient to prevent recognition by V3-targeting antibodies.
(A) Expi293F cells expressing wild-type BaL (gray), BaL-QES.i01 (magenta), or BaL-QES.i02 gp160 (purple) were incubated with anti-V3 region monoclonal antibodies (from left to right) 2442, 268-D IV, 39F, and 3074. Bound antibody was detected by flow cytometry (n = 3, means ± the SD). (B) Binding of V3-targeting antibodies to cells expressing wild-type (gray) or QES.i01.c01 (blue; containing additional core mutations that limit CD4 interactions) BaL Env. The data are means (n = 2), with error bars showing the range.
Heredia, J. D., Park, J., Choi, H., Gill, K. S., & Procko, E. (2019). Conformational engineering of HIV-1 Env based on mutational tolerance in the CD4 and PG16 bound states. Journal of virology, 93(11), e00219-19.
Specifications
- Immunogen
- HIV-1 gp160 protein
- Host Species
- Human
- Type
- Human IgG1,λ
- Specificity
- HIV-1
- Species Reactivity
- HIV-1
- Clone
- 268-D
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 268-D"
See other products for "HIV-1 gp160"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-177 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-177) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-178 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 3H+109L) | WB, ELISA, FuncS | Human IgG |
| PABL-179 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128) | WB, ELISA, FuncS | Human IgG |
| PABL-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C) | WB, ELISA, Neut, FuncS | Human IgG, κ |
| PABL-181 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01) | FC, Neut, FuncS | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-3882CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone P3C8); Fab Fragment | Neut | Mouse Fab |
| MRO-3883CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone P3E1); Fab Fragment | Neut | Mouse Fab |
| MRO-3884CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone P4D7); Fab Fragment | Neut | Mouse Fab |
| MRO-3885CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone PC5009); Fab Fragment | ELISA, WB | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-075LC | Anti-HIV-1 gp160 Recombinant Antibody (24G3) | WB, ELISA | Human antibody |
| MRO-080LC | Anti-HIV-1 gp160 Recombinant Antibody (81C7) | ELISA | Human antibody |
| MRO-091LC | Anti-HIV-1 gp160 Recombinant Antibody (MAb CL1) | ELISA | Human antibody |
| MRO-100LC | Anti-HIV-1 gp160 Recombinant Antibody (N7019b) | ELISA | Human antibody |
| MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
| MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
| MRO-089LC | Anti-HIV-1 gp160 Recombinant Antibody (2H8) | ELISA | Mouse antibody |
| MRO-086LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1C1) | ELISA | Mouse antibody |
| MRO-087LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1H9) | ELISA | Mouse antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3904CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone MF169.1); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3905CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone MF170.1); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3906CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 322-151); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3907CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 4C11.D8); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3908CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 3D3.B8); scFv Fragment | ELISA, WB | Mouse scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for PABW-163. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.