Anti-Human CD147 Recombinant Antibody (Gavilimomab) (CAT#: TAB-156)
Recombinant monoclonal antibody to CD147. Gavilimomab (also known as ABX-CBL) is a mouse monoclonal antibody intended for use as an immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
Figure 2 Testis
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
Figure 3 Heart muscle
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
Figure 5 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
Figure 6 Kidney
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
Specifications
- Immunogen
- Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer).
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgM
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
- CAS
- 244096-20-6
- Generic Name
- Gavilimomab
- Related Disease
- Allograft rejection
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- At -20°C for one year.
Target
- Alternative Names
- Gavilimomab;244096-20-6;ABX-CBL;ABX-CBL;BSG;basigin (Ok blood group);basigin (OK blood group) , OK;basigin;CD147;EMMPRIN;CD147 antigen;OK blood group antigen;collagenase stimulatory factor;leukocyte activation antigen M6;extracellular matrix metalloprotei
- Gene ID
- 682
- UniProt ID
- P35613
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Gavilimomab"
Afuco™ Anti-BSG ADCC Recombinant Antibody (Gavilimomab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD147. Gavilimomab (also known as ABX-CBL) is a mouse monoclonal antibody intended for use as an immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy.
See other products for "BSG"
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B050(A) | Recombinant Anti-human BSG Intrabody [(D-Arg)9] | WB, ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B050(G) | Recombinant Anti-human BSG Intrabody [+36 GFP] | IF, FC, FuncS | scFv-(+36GFP) |
| IAB-B050(T) | Recombinant Anti-human BSG Intrabody [Tat] | WB, ICC, FuncS | scFv-Tat |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-883 | Anti-Human CD147/BSG Recombinant Antibody (Ziralimumab) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgM |
| TAB-1289CL | Human Anti-BSG Recombinant Antibody (TAB-1289CL) | Cyt, FC | Human IgG |
| TAB-1290CL | Human Anti-BSG Recombinant Antibody (TAB-1290CL) | Cyt, FC | Human IgG |
| TAB-1285CL-S(P) | Anti-Human BSG Recombinant Antibody scFv Fragment (2.6.1 (ABX-RB2)) | Inhib | Fully human antibody |
| TAB-1290CL-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (TAB-1290CL-S(P)) | FC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-461 | Human Anti-BSG Recombinant Antibody (clone 5F6); Fab Fragment | WB, FuncS | Chimeric (mouse/human) Fab |
| HPAB-3079LY-F(E) | Mouse Anti-BSG Recombinant Antibody; Fab Fragment (HPAB-3079LY-F(E)) | IHC, Inhib | Mouse Fab |
| HPAB-3080LY-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (HPAB-3080LY-F(E)) | IHC, Inhib | Chimeric (mouse/human) Fab |
| HPAB-0356-FY-F(E) | Human Anti-BSG Recombinant Antibody (clone HcHAbl8); Fab Fragment | Inhib | Humanized Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-070CQ | Human Anti-BSG Recombinant Antibody (clone Ab-1) | ELISA, Block | Human IgG1, κ |
| NEUT-071CQ | Mouse Anti-BSG Recombinant Antibody (clone HIM6) | FC, WB, IHC, Block | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0389 | Hi-Affi™ Rabbit Anti-BSG Recombinant Antibody (clone DS389AB) | ICC, IHC-P, WB | Rabbit IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-020CN | Mouse Anti-BSG Recombinant Antibody (clone 5F6) | ELISA, Block, FuncS | Mouse IgG1 |
| NS-020CN-F(E) | Mouse Anti-BSG Recombinant Antibody (clone 5F6); Fab Fragment | ELISA | Mouse Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0126CQ | Mouse Anti-BSG Recombinant Antibody (clone HAb18) | ELISA, IF, WB | Mouse IgG1 |
| MRO-1735-CN | Rabbit Anti-BSG Polyclonal Antibody (MRO-1735-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY241 | Recombinant Mouse Anti-BSG Antibody (clone 2D3A9) | ELISA, WB, IHC, ICC, FC | Mouse IgG1 |
| VS3-FY242 | Recombinant Mouse Anti-BSG Antibody (clone 2D8C11) | ELISA, IHC, FC | Mouse IgG2b |
| VS3-FY243 | Recombinant Mouse Anti-BSG Antibody (clone 5A6F8) | ELISA, IHC, FC | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-403 | Mouse Anti-BSG Recombinant Antibody (clone 6H8); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-M0438-YC-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (HPAB-M0438-YC-S(P)) | ELISA, IHC, Inhib | Human scFv |
| HPAB-M0439-YC-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (HPAB-M0439-YC-S(P)) | ELISA | Human scFv |
| HPAB-3188LY-S(P) | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-01); scfv Fragment | ELISA, FC | Humanized scfv |
| HPAB-3189LY-S(P) | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-02); scfv Fragment | ELISA, FC | Humanized scfv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-156 | Afuco™ Anti-BSG ADCC Recombinant Antibody (Gavilimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-883 | Afuco™ Anti-BSG ADCC Recombinant Antibody (Ziralimumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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