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Anti-Human CD18 Recombinant Antibody F(ab')₂ Fragment( Erlizumab)

Anti-Human CD18 Recombinant Antibody F(ab')₂ Fragment( Erlizumab) (CAT#: TAB-154-F(E))

Recombinant antibody Fragment F(ab')₂ to CD18. Erlizumab, also known as rhuMAb, is a recombinant humanized monoclonal antibody that was an experimental immunosuppressive drug. Erlizumab treats heart attack, stroke, and traumatic shock.

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Tested Data
Gene Expression
Datasheet
MSDS
COA

SDS-PAGE

Figure 1 Anti-Human CD18 Recombinant Antibody, hIgG1 (TAB-154-F(E)) in SDS-PAGE

Figure 1 Anti-Human CD18 Recombinant Antibody, hIgG1 (TAB-154-F(E)) in SDS-PAGE

SDS-PAGE analysis of TAB-154-F(E) in non-reduced (Lane 2) and reduced (Lane 1) conditions. Gel stained for 30 minutes with Coomassie Blue. As a result, different β-mercaptoethanol-reduced proteins (Heavy chain and Light chain) migrate as about 50 kDa and 25 kDa, respectively.

The purity of TAB-154-F(E) was greater than 95% as determined by SDS-PAGE.

SEC-HPLC

Figure 2 Anti-Human CD18 Recombinant Antibody, hIgG1 (TAB-154-F(E)) in HPLC

Figure 2 Anti-Human CD18 Recombinant Antibody, hIgG1 (TAB-154-F(E)) in HPLC

The purity of TAB-154-F(E) was greater than 95% as determined by SEC-HPLC.

Subcellular Location

Figure 1 IF staining of human cell line U-2 OS

Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg

Figure 2 IF staining of human cell line EFO-21

Figure 2 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg

Figure 3 IF staining of human cell line BJ

Figure 3 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg

RNA Expression

Figure 4 RNA cell line category: Group enriched (THP-1, U-937)

Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2

Figure 4 RNA cell line category: Group enriched (THP-1, U-937)

Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
Tissue / cell preparation (Human). (Leucocytes of a patient suffering from a LGL-type leukaemia).

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1

Specificity
Tested positive against native human antigen.

Species Reactivity
Human

Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.

CAS
211323-03-4

Generic Name
Erlizumab

Related Disease
Unknown

Product Property

Purity
>95.0% as determined by analysis by SDS-PAGE.

Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Target

Alternative Names
Erlizumab;211323-03-4;rhuMAb CD18;rhuMAb;ITGB2;integrin, beta 2 (complement component 3 receptor 3 and 4 subunit);CD18, integrin, beta 2 (antigen CD18 (p95), lymphocyte function associated antigen 1;macrophage antigen 1 (mac 1) beta subunit) , MFI7;integr

Gene ID
3689

UniProt ID
P05107

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Fab Fragment Antibody

CAT	Product Name	Application	Type
DrMAB-980	Recombinant Mouse Anti-Human ITGB2 Antibody F(ab')₂ Fragment, clone IB4	FC, Inhib	F(ab')2
FAMAB-0203CQ-F(E)	Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3); Fab Fragment	ELISA, WB, Block	Mouse Fab
FAMAB-0204CQ-F(E)	Human Anti-ITGB2 Recombinant Antibody (clone h60.3); Fab Fragment	ELISA, WB, Block	Human Fab
HPAB-1376WJ-F(E)	Human Anti-ITGB2 Recombinant Antibody; Fab Fragment (clone huH52)	ELISA, WB	Human Fab
HPAB-1569WJ-F(E)	Mouse Anti-ITGB2 Recombinant Antibody; Fab Fragment (clone 1B4)	ELISA, WB, IF	Mouse Fab

Single-domain Antibody

CAT	Product Name	Application	Type
NABG-099	Recombinant Anti-Human ITGB2 VHH Single Domain Antibody	ELISA, IHC, FC, FuncS	Llama VHH

Humanized Antibody

CAT	Product Name	Application	Type
TAB-044	Anti-Human ITGB2 Recombinant Antibody (Rovelizumab)	Neut, ELISA, IF, IP, FuncS, FC, IHC	IgG4
TAB-461CL	Human Anti-ITGB2 Recombinant Antibody (TAB-461CL)	ELISA	Human IgG
TAB-1582CL	Anti-Human ITGB2 Recombinant Antibody (Hu23F2G (also known as LeukArrest and Rovelizumab))	IP, FuncS	Humanized antibody
TAB-1582CL-S(P)	Anti-Human ITGB2 Recombinant Antibody scFv Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab))	Inhib	Humanized antibody
TAB-1582CL-F(E)	Anti-Human ITGB2 Recombinant Antibody Fab Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab))	Inhib	Humanized antibody

Mouse Antibody

CAT	Product Name	Application	Type
TAB-1581CL	Anti-Human ITGB2 Recombinant Antibody (23F2G)	Inhib
TAB-1581CL-S(P)	Anti-Human ITGB2 Recombinant Antibody scFv Fragment (23F2G)	Inhib
TAB-1581CL-F(E)	Anti-Human ITGB2 Recombinant Antibody Fab Fragment (23F2G)	Inhib

Chicken IgY Antibody

CAT	Product Name	Application	Type
BRD-0298MZ	Chicken Anti-ITGB2 Polyclonal IgY	WB	Chicken antibody

Blocking Antibody

CAT	Product Name	Application	Type
NEUT-1590CQ	Recombinant Mouse Anti-ITGB2 Antibody (MEM-48)	BL, FC, IHC-Fr, IHC-P, IP, WB	IgG1
NEUT-1591CQ	Recombinant Mouse Anti-ITGB2 Antibody (TS1/18)	BL, FC, ICC/IF, IHC, WB	IgG1
NEUT-1592CQ	Recombinant Mouse Anti-ITGB2 Antibody (YFC118.12)	FC, BL	IgG1, κ
NEUT-1593CQ	Recombinant Mouse Anti-ITGB2 Antibody (MEM-148)	FC, IP, WB, BL, FuncS	IgG1
NEUT-1594CQ	Recombinant Hamster Anti-Itgb2 Antibody (2E6)	BL, ICC, IP, FC	IgG

Rabbit Monoclonal Antibody

CAT	Product Name	Application	Type
MOR-1884	Hi-Affi™ Recombinant Rabbit Anti-ITGB2 Monoclonal Antibody (DS1884AB)	IP, WB	IgG

scFv Fragment Antibody

CAT	Product Name	Application	Type
FAMAB-0203CQ-S(P)	Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3); scFv Fragment	ELISA, WB, Block	Mouse scFv
HPAB-1207WJ-S(P)	Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3); scFv Fragment	ELISA	Human scFv
HPAB-1874-FY-F(E)	Human Anti-ITGB2 Recombinant Antibody (clone NA-8); scFv Fragment	Block	Humanized scFv
HPAB-1376WJ-S(P)	Human Anti-ITGB2 Recombinant Antibody; scFv Fragment (clone huH52)	ELISA, WB	Human scFv
HPAB-1569WJ-S(P)	Mouse Anti-ITGB2 Recombinant Antibody; scFv Fragment (clone 1B4)	ELISA, WB, IF	Mouse scFv

ADCC Enhanced Antibody

CAT	Product Name	Application	Type
AFC-TAB-044	Afuco™ Anti-ITGB2 ADCC Recombinant Antibody (Rovelizumab), ADCC Enhanced	Neut, ELISA, IF, IP, FuncS, FC	ADCC enhanced antibody

Recombinant Antibody

CAT	Product Name	Application	Type
FN-085CQ	Recombinant Rat Anti-ITGB2 Antibody (C71/16)	IHC-Fr, FC, IP, FuncS	Rat IgG2a
HPAB-1207WJ	Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3)	ELISA	Human IgG
VS3-CJ398	Mouse Anti-ITGB2 Recombinant Antibody (VS3-CJ398)	WB, IHC-P	Mouse IgG1
VS3-CJ399	Mouse Anti-ITGB2 Recombinant Antibody (clone TS1/18.1.2)	IF, FC	Mouse IgG1
VS3-XY934	Mouse Anti-ITGB2 Recombinant Antibody, FITC (clone 4ATS1/18.1.2.11)	FC, IF	Mouse IgG1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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