Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
Figure 1 Cytotoxicity of the siplizumab.
Mean ( standard error) NK cell activity at day 1 before siplizumab infusion and at study days 2 and 33 (P=95).
Pruett, T. L., McGory, R. W., Wright, F. H., Pescovitz, M. D., Yang, H., & McClain, J. B. (2009, November). Safety profile, pharmacokinetics, and pharmacodynamics of siplizumab, a humanized anti-CD2 monoclonal antibody, in renal allograft recipients. In Transplantation proceedings (Vol. 41, No. 9, pp. 3655-3661). Elsevier.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-CD2 ADCC Recombinant Antibody (Siplizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B074(A) | Recombinant Anti-human CD2 Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
IAB-B074(G) | Recombinant Anti-human CD2 Intrabody [+36 GFP] | ELISA, IF, Neut, FuncS | scFv-(+36GFP) |
IAB-B074(T) | Recombinant Anti-human CD2 Intrabody [Tat] | ELISA, Neut, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-110CL | Anti-Human CD2 Recombinant Antibody (BTI-322) | FuncS | Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-295CQ | Mouse Anti-CD2 Recombinant Antibody (clone CBL975) | WB, FC, Neut, IHC | Mouse IgG1, κ |
NEUT-296CQ | Mouse Anti-CD2 Recombinant Antibody (clone RPA-2.10) | WB, Neut, FC, IHC, IHC-Fr | Mouse IgG1, κ |
NEUT-297CQ | Mouse Anti-CD2 Recombinant Antibody (clone TS1/8) | Neut, FC, CyTOF | Mouse IgG1 |
NEUT-299CQ | Rat Anti-CD2 Recombinant Antibody (clone 12-15) | Neut, FC, IP | Rat IgG1, κ |
NEUT-300CQ | Rat Anti-CD2 Recombinant Antibody (clone RM2) | FC, FuncS, Neut | Rat IgG2b, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-298CQ | Mouse Anti-CD2 Recombinant Antibody (clone TS218) | Block, FC, IP, WB | Mouse IgG1, κ |
NEUT-301CQ | Rat Anti-CD2 Recombinant Antibody (clone RM2-5) | FC, IP, Block, Costim | Rat IgG2b, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0542 | Hi-Affi™ Rabbit Anti-CD2 Recombinant Antibody (clone DS542AB) | WB, IHC, ICC, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0019-LSX | Human Anti-CD2 Recombinant Antibody (clone 35.1) | ELISA, FuncS | Chimeric IgG |
ZG-0087J | Mouse Anti-CD2 Recombinant Antibody (clone 3F3) | IHC-P, IF | Mouse IgG |
ZG-0088J | Mouse Anti-CD2 Recombinant Antibody (ZG-0088J) | IHC-P, IF | Mouse IgG |
ZG-0089J | Mouse Anti-CD2 Recombinant Antibody (ZG-0089J) | IHC-P, IF | Mouse IgG |
ZG-0903F | Mouse Anti-CD2 Recombinant Antibody (clone T6.3) | FC | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0019-LSX-S(P) | Human Anti-CD2 Recombinant Antibody (clone 35.1); scFv Fragment | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0019-LSX-F(E) | Human Anti-CD2 Recombinant Antibody (clone 35.1); Fab Fragment | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-104 | Afuco™ Anti-CD2 ADCC Recombinant Antibody (Siplizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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