Anti-Human CD2 Recombinant Antibody (Siplizumab) (CAT#: TAB-104)

Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Cytotoxicity of the siplizumab.

Figure 1 Cytotoxicity of the siplizumab.

Mean ( standard error) NK cell activity at day 1 before siplizumab infusion and at study days 2 and 33 (P=95).

Pruett, T. L., McGory, R. W., Wright, F. H., Pescovitz, M. D., Yang, H., & McClain, J. B. (2009, November). Safety profile, pharmacokinetics, and pharmacodynamics of siplizumab, a humanized anti-CD2 monoclonal antibody, in renal allograft recipients. In Transplantation proceedings (Vol. 41, No. 9, pp. 3655-3661). Elsevier.


Specifications

  • Immunogen
  • Human CD2 recombinant protein
  • Host Species
  • Rat
  • Derivation
  • Humanized (from rat)
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • ELISA, IP, FC, FuncS, Neut, IF, ICC
  • CAS
  • 288392-69-8
  • Generic Name
  • Siplizumab
  • Related Disease
  • Psoriasis

Product Property

  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Storage
  • At -20°C for one year.

Applications

  • Application Notes
  • The CD2 antibody has been reported in applications of Cyt.

Target

  • Alternative Names
  • Siplizumab;288392-69-8;MEDI-507;CD2;CD2 molecule;CD2 antigen (p50), sheep red blood cell receptor , SRBC;T-cell surface antigen CD2;LFA-3 receptor;rosette receptor;erythrocyte receptor;lymphocyte-function antigen-2;T-cell surface antigen T11/Leu-5;CD2 ant

Related Resources

  • Biosimilar Overview
Please refer to Siplizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Siplizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Siplizumab"

Afuco™ Anti-CD2 ADCC Recombinant Antibody (Siplizumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.

See other products for "CD2"

Intrabody

CAT Product Name Application Type
IAB-B074(A) Recombinant Anti-human CD2 Intrabody [(D-Arg)9] PCA, WB, FuncS scFv-(D-Arg)9
IAB-B074(G) Recombinant Anti-human CD2 Intrabody [+36 GFP] ELISA, IF, Neut, FuncS scFv-(+36GFP)
IAB-B074(T) Recombinant Anti-human CD2 Intrabody [Tat] ELISA, Neut, FuncS scFv-Tat

Rat Antibody

CAT Product Name Application Type
TAB-110CL Anti-Human CD2 Recombinant Antibody (BTI-322) FuncS Antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-295CQ Mouse Anti-CD2 Recombinant Antibody (clone CBL975) WB, FC, Neut, IHC Mouse IgG1, κ
NEUT-296CQ Mouse Anti-CD2 Recombinant Antibody (clone RPA-2.10) WB, Neut, FC, IHC, IHC-Fr Mouse IgG1, κ
NEUT-297CQ Mouse Anti-CD2 Recombinant Antibody (clone TS1/8) Neut, FC, CyTOF Mouse IgG1
NEUT-299CQ Rat Anti-CD2 Recombinant Antibody (clone 12-15) Neut, FC, IP Rat IgG1, κ
NEUT-300CQ Rat Anti-CD2 Recombinant Antibody (clone RM2) FC, FuncS, Neut Rat IgG2b, λ

Blocking Antibody

CAT Product Name Application Type
NEUT-298CQ Mouse Anti-CD2 Recombinant Antibody (clone TS218) Block, FC, IP, WB Mouse IgG1, κ
NEUT-301CQ Rat Anti-CD2 Recombinant Antibody (clone RM2-5) FC, IP, Block, Costim Rat IgG2b, λ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0542 Hi-Affi™ Rabbit Anti-CD2 Recombinant Antibody (clone DS542AB) WB, IHC, ICC, IP Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0019-LSX-S(P) Human Anti-CD2 Recombinant Antibody (clone 35.1); scFv Fragment ELISA Mouse scFv

Fab Fragment Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-104 Afuco™ Anti-CD2 ADCC Recombinant Antibody (Siplizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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