Anti-Human CD20 Recombinant Antibody (Tositumomab) (CAT#: TAB-017)
Recombinant monoclonal antibody to Human CD20. Tositumomab is a drug for the treatment of follicular lymphoma. It is an IgG2a anti-CD20 monoclonal antibody derived from immortalized mouse cells. Tositumomab is applied in a sequential infusion followed by iodine (131I) tositumomab, which is the same antibody covalently bound to the radionuclide iodine-131 (131I). 131I emits both beta and gamma radiation and decays with a half-life of 8 days.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line REH
(Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
(Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
Figure 4 Colon
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
Figure 5 Bone marrow
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
Figure 6 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG2a - lambda
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
- Trade name
- bexxar
- CAS
- 192391-48-3
- Generic Name
- Tositumomab
- ATC Code
- V10XA53
- DrugBank
- DB00081
- UNII
- 0343IGH41U
- ChEMBL
- CHEMBL1201604
- MW
- 143,859.7 g/mol
- Related Disease
- Non-Hodgkin's lymphoma (NHL) (follicular, CD20 positive, following chemotherapy relapse)
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Tositumomab;bexxar;192391-48-3;DB00081 MS4A1;membrane-spanning 4-domains, subfamily A, member 1;CD20;B-lymphocyte antigen CD20;B1;Bp35;MS4A2;CD20 antigen;CD20 receptor;leukocyte surface antigen Leu-16;B-lymphocyte cell-surface antigen B1;S7;CVID5;LEU-16;M
- Gene ID
- 931
- UniProt ID
- P11836
Related Resources
Please refer to Tositumomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tositumomab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Tositumomab"
Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Tositumomab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human CD20. Tositumomab is a drug for the treatment of follicular lymphoma. It is an IgG2a anti-CD20 monoclonal antibody derived from immortalized mouse cells. Tositumomab is applied in a sequential infusion followed by iodine (131I) tositumomab, which is the same antibody covalently bound to the radionuclide iodine-131 (131I). 131I emits both beta and gamma radiation and decays with a half-life of 8 days.
See other products for "MS4A1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-019 | Human Anti-MS4A1 Recombinant Antibody (clone C2H7) | WB, IF, FuncS | Chimeric (mouse/human) IgG |
| PABL-422 | Human Anti-MS4A1 Recombinant Antibody (clone 2F2) | WB, ELISA, FuncS | Human IgG1,κ |
| PABL-423 | Mouse Anti-MS4A1 Recombinant Antibody (clone GA101) | FC, Activ, Agonist, IF, WB, Cyt, FuncS | Mouse IgG |
| HPAB-0018-FY | Human Anti-MS4A1 Recombinant Antibody (HPAB-0018-FY) | FC | Humanized IgG1 |
| HPAB-0021-FY | Human Anti-MS4A1 Recombinant Antibody (clone hu3D9) | FC | Humanized IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-143 | Mouse Anti-MS4A1 Recombinant Antibody (clone KM3575); scFv Fragment | WB | Mouse scFv |
| FAMAB-0241CQ-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); Fab Fragment | ELISA, FC, IHC, IP | Mouse Fab |
| HPAB-0465LY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone CBL004LY); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0466LY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone CBL005LY); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1896LY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone muCD37-3); Fab Fragment | ELISA, Inhib | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0001CL | Human Anti-MS4A1 Recombinant Antibody (TAB-0001CL) | ELISA, ADCC, CDC | Human IgG |
| TAB-1703CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1703CL) | FC, CDC, IP | Human IgG1, κ |
| TAB-1704CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1704CL) | IP | Human IgG1, κ |
| TAB-1705CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1705CL) | Cyt, FC, FuncS | Human IgG3, κ |
| TAB-1648CL-F(E) | Anti-MS4A1 Recombinant Antibody Fab Fragment (MEDI-552) | Inhib |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1638CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL) | ADCC, CDC | Humanized IgG |
| TAB-1639CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL) | ADCC, CDC, Apop | Humanized IgG |
| TAB-1640CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1640CL) | ADCC, CDC, Apop, FuncS | Humanized IgG |
| TAB-1641CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1641CL) | ADCC, CDC, Apop | Humanized IgG |
| TAB-1642CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1642CL) | ADCC, CDC | Humanized IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1665CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1665CL) | CDC | Chimeric (mouse/human) IgG |
| TAB-1666CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1666CL) | CDC | Chimeric (mouse/human) IgG |
| TAB-1667CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1667CL) | CDC | Chimeric (mouse/human) IgG |
| TAB-1668CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1668CL) | CDC | Chimeric (mouse/human) IgG |
| TAB-1669CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1669CL) | CDC | Chimeric (mouse/human) IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1657CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1422) | Apop, FuncS | |
| TAB-1658CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1791) | Apop, FuncS | |
| TAB-1660CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1712) | Apop, FuncS | |
| TAB-1661CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1402) | Apop, FuncS | |
| TAB-1662CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1736) | Apop, FuncS |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-059LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-060LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-154LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-155LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated | ELISA | Humanized antibody |
| Gly-158LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-138LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Hyper-galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
High-mannose Glycoform
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
| MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) | ELISA, FuncS | Camelid VHH |
| HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) | ELISA | Camelid VHH |
| HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) | ELISA | Camelid VHH |
| HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) | ELISA | Camelid VHH |
| HPAB-M0708-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD17) | ELISA | Camelid VHH |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-H39 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ibritumomab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H51 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Obinutuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-007ML | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Blontuvetmab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0614-WJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0614-WJ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0528-YJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone 2F4); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-0529-YJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone ch2F4); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1885-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1885-FY-F(E)) | ELISA, FC | Human Fab |
| HPAB-1954-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone BD31-7); scFv Fragment | Cyt | Humanized scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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