Anti-Human CD22 Recombinant Antibody (Moxetumomab Pasudotox) (CAT#: TAB-183-F(E))

Recombinant monoclonal antibody to CD22. Moxetumomab pasudotox is an anti-CD22 mouse monoclonal antibody designed for the treatment of cancer.

Host: Mouse

Isotype: Fv - disulfide stabilized

Applications: FuncS, IF, Neut, ELISA, FC, IP, ICC


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Pharmacokinetics of moxetumomab pasudotox.

(A) Peak plasma levels on cycle 1 are compared between dose 1 (day 1) and dose 3 (day 5). (B) Peak plasma levels and (C) areas under the curve (AUCs) are shown for cycle 1, day 5 at each of the dose levels.

Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.

Figure 2 Toxicity of moxetumomab pasudotox. Incidence of toxicity by cycle is shown by grade for all 114 cycles administered to 28 patients.

CPK, creatine phosphokinase; effu, effusion; GGT, γ-glutamyltransferase; HCL, hairy cell leukemia; H&N, head and neck; HGB, hemoglobin; HUS, hemolytic uremic syndrome; Hypo-MG, hypomagnesemia; SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase.

Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • Fv - disulfide stabilized
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • FuncS, IF, Neut, ELISA, FC, IP, ICC
  • CAS
  • 1020748-57-5
  • Generic Name
  • Moxetumomab pasudotox
  • MW
  • 63.5 kDa
  • Related Disease
  • Hairy cell leukemia (HCL)

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Applications

  • Application Notes
  • The CD22 antibody has been reported in applications of PK, Cyt.

Target

  • Alternative Names
  • Moxetumomab pasudotox;1020748-57-5;CAT-8015;HA22;R490A;BL22 immunotoxin;CD22;CD22 molecule;CD22 antigen;B-cell receptor CD22;sialic acid binding Ig like lectin 2;SIGLEC 2;SIGLEC2;BL-CAM;T-cell surface antigen Leu-14;B-lymphocyte cell adhesion molecule;sia

Related Resources

  • Biosimilar Overview
Please refer to Moxetumomab Pasudotox Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Moxetumomab Pasudotox.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CD22"

Mouse Antibody

CAT Product Name Application Type
TAB-047-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment(Bectumomab) ELISA, FC, IP, FuncS, IF, Neut, WB Fab' - G2a - kappa
TAB-1714CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1714CL-S(P)) ELISA, WB Mouse scFv
TAB-003LC-S(P) Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-004LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-005LC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-005LC-S(P)) FC Mouse scFv

Immunotoxin

CAT Product Name Application Type
AGTO-G077S Anti-CD22 immunotoxin RFB4 (IgG)-Sap Cytotoxicity assay, Function study
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L048D anti-CD22 immunotoxin RFB4 (scFv)-DT Cytotoxicity assay, Functional assay
AGTO-L048G anti-CD22 immunotoxin RFB4 (scFv)-Gel Cytotoxicity assay, Functional assay
AGTO-L048R anti-CD22 immunotoxin RFB4 (scFv)-RTA Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-1715CL Anti-Human CD22 Recombinant Antibody (12C5) Cyt, FuncS Fully human antibody
TAB-1716CL Anti-Human CD22 Recombinant Antibody (19A3) Cyt, FuncS Fully human antibody
TAB-1717CL Anti-Human CD22 Recombinant Antibody (16F7) Cyt, FuncS Fully human antibody
TAB-1718CL Anti-Human CD22 Recombinant Antibody (23C6) Cyt, FuncS Fully human antibody
TAB-1719CL Anti-Human CD22 Recombinant Antibody (4G6) ELISA Fully human antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-1724CL Human Anti-CD22 Recombinant Antibody (TAB-1724CL) Inhib Chimeric (mouse/human) IgG1, κ
TAB-1724CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) Inhib Chimeric (mouse/human) Fab
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) ELISA Chimeric antibody (mouse/human)
TAB-001LC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) ELISA Mouse scFv
TAB-001LC-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) ELISA Chimeric antibody (mouse/human)

Humanized Antibody

CAT Product Name Application Type
TAB-1725CL Human Anti-CD22 Recombinant Antibody (TAB-1725CL) Block, Cyt, ELISA, FuncS Humanized IgG
TAB-1729CL Human Anti-CD22 Recombinant Antibody (TAB-1729CL) IF, FC Humanized IgG
TAB-1725CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) Block, Cyt, ELISA, FuncS Humanized Fab
TAB-1729CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) IF, FC Humanized Fab
TAB-002LC-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) ELISA, SPR Humanized antibody

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Recombinant Antibody

CAT Product Name Application Type
MOB-0349MZ Mouse Anti-CD22 Recombinant Antibody (clone 5LB129) ELISA Mouse IgG1
FAMAB-0046YC Mouse Anti-CD22 Recombinant Antibody (clone m5/44) ELISA, Cyt Mouse IgG1
FAMAB-0047YC Human Anti-CD22 Recombinant Antibody (clone g5/44) ELISA, Cyt Humanized IgG4
FAMAB-0048YC Human Anti-CD22 Recombinant Antibody (clone ch5/44) ELISA Chimeric (mouse/human) IgG
HPAB-0709-FY Mouse Anti-CD22 Recombinant Antibody (clone AB008) ELISA Mouse IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0194-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) ELISA Mouse Fab
HPAB-0195-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) ELISA Human Fab
HPAB-0196-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) ELISA Mouse Fab
HPAB-0197-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) ELISA Human Fab
HPAB-0198-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) ELISA, FC Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0249-FY-S(P) Recombinant Human Anti-CD22 Antibody scFv Fragment F Human scFv
HPAB-0709-FY-F(E) Mouse Anti-CD22 Recombinant Antibody (clone AB008); scFv Fragment ELISA Mouse scFv
HPAB-0370-FY-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0370-FY-S(P)) ELISA Humanized scFv
HPAB-0371-FY-S(P) Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0371-FY-S(P)) Inhib Humanized scFv
HPAB-2052-FY-S(P) Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment FC Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-183-F(E). Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
Send Inquiry
© 2023 Creative BioLabs. All Rights Reserved
  • 0
  • 0
Cart