Recombinant monoclonal antibody to CD22. Moxetumomab pasudotox is an anti-CD22 mouse monoclonal antibody designed for the treatment of cancer.
Host: Mouse
Isotype: Fv - disulfide stabilized
Applications: FuncS, IF, Neut, ELISA, FC, IP, ICC
Figure 1 Pharmacokinetics of moxetumomab pasudotox.
(A) Peak plasma levels on cycle 1 are compared between dose 1 (day 1) and dose 3 (day 5). (B) Peak plasma levels and (C) areas under the curve (AUCs) are shown for cycle 1, day 5 at each of the dose levels.
Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.
Figure 2 Toxicity of moxetumomab pasudotox. Incidence of toxicity by cycle is shown by grade for all 114 cycles administered to 28 patients.
CPK, creatine phosphokinase; effu, effusion; GGT, γ-glutamyltransferase; HCL, hairy cell leukemia; H&N, head and neck; HGB, hemoglobin; HUS, hemolytic uremic syndrome; Hypo-MG, hypomagnesemia; SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase.
Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
TAB-047-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment(Bectumomab) | ELISA, FC, IP, FuncS, IF, Neut, WB | Fab' - G2a - kappa |
TAB-1714CL-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1714CL-S(P)) | ELISA, WB | Mouse scFv |
TAB-003LC-S(P) | Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment | FC | |
TAB-004LC-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment | FC | |
TAB-005LC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-005LC-S(P)) | FC | Mouse scFv |
CAT | Product Name | Application | Type |
AGTO-G077S | Anti-CD22 immunotoxin RFB4 (IgG)-Sap | Cytotoxicity assay, Function study | |
AGTO-L048E | anti-CD22 immunotoxin RFB4 (scFv)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L048D | anti-CD22 immunotoxin RFB4 (scFv)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L048G | anti-CD22 immunotoxin RFB4 (scFv)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L048R | anti-CD22 immunotoxin RFB4 (scFv)-RTA | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
TAB-1715CL | Anti-Human CD22 Recombinant Antibody (12C5) | Cyt, FuncS | Fully human antibody |
TAB-1716CL | Anti-Human CD22 Recombinant Antibody (19A3) | Cyt, FuncS | Fully human antibody |
TAB-1717CL | Anti-Human CD22 Recombinant Antibody (16F7) | Cyt, FuncS | Fully human antibody |
TAB-1718CL | Anti-Human CD22 Recombinant Antibody (23C6) | Cyt, FuncS | Fully human antibody |
TAB-1719CL | Anti-Human CD22 Recombinant Antibody (4G6) | ELISA | Fully human antibody |
CAT | Product Name | Application | Type |
TAB-1724CL | Human Anti-CD22 Recombinant Antibody (TAB-1724CL) | Inhib | Chimeric (mouse/human) IgG1, κ |
TAB-1724CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) | Inhib | Chimeric (mouse/human) Fab |
TAB-001LC | Human Anti-CD22 Recombinant Antibody (TAB-001LC) | ELISA | Chimeric antibody (mouse/human) |
TAB-001LC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) | ELISA | Mouse scFv |
TAB-001LC-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
TAB-1725CL | Human Anti-CD22 Recombinant Antibody (TAB-1725CL) | Block, Cyt, ELISA, FuncS | Humanized IgG |
TAB-1729CL | Human Anti-CD22 Recombinant Antibody (TAB-1729CL) | IF, FC | Humanized IgG |
TAB-1725CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) | Block, Cyt, ELISA, FuncS | Humanized Fab |
TAB-1729CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) | IF, FC | Humanized Fab |
TAB-002LC-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) | ELISA, SPR | Humanized antibody |
CAT | Product Name | Application | Type |
Gly-001LC | Recombinant Anti-Human CD22 Antibody (Fab glycosylation) | ELISA, FC | Mouse antibody |
CAT | Product Name | Application | Type |
Gly-111LC | Recombinant Anti-Human CD22 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
MOB-0349MZ | Mouse Anti-CD22 Recombinant Antibody (clone 5LB129) | ELISA | Mouse IgG1 |
FAMAB-0046YC | Mouse Anti-CD22 Recombinant Antibody (clone m5/44) | ELISA, Cyt | Mouse IgG1 |
FAMAB-0047YC | Human Anti-CD22 Recombinant Antibody (clone g5/44) | ELISA, Cyt | Humanized IgG4 |
FAMAB-0048YC | Human Anti-CD22 Recombinant Antibody (clone ch5/44) | ELISA | Chimeric (mouse/human) IgG |
HPAB-0709-FY | Mouse Anti-CD22 Recombinant Antibody (clone AB008) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
NEUT-315CQ | Rat Anti-CD22 Recombinant Antibody (clone 2D6) | Block | Rat IgG1, κ |
CAT | Product Name | Application | Type |
MOR-0545 | Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) | IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
HPAB-0194-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) | ELISA | Mouse Fab |
HPAB-0195-LSX-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) | ELISA | Human Fab |
HPAB-0196-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) | ELISA | Mouse Fab |
HPAB-0197-LSX-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) | ELISA | Human Fab |
HPAB-0198-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
HPAB-0249-FY-S(P) | Recombinant Human Anti-CD22 Antibody scFv Fragment | F | Human scFv |
HPAB-0709-FY-F(E) | Mouse Anti-CD22 Recombinant Antibody (clone AB008); scFv Fragment | ELISA | Mouse scFv |
HPAB-0370-FY-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0370-FY-S(P)) | ELISA | Humanized scFv |
HPAB-0371-FY-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0371-FY-S(P)) | Inhib | Humanized scFv |
HPAB-2052-FY-S(P) | Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment | FC | Human scFv |
CAT | Product Name | Application | Type |
AFC-TAB-176 | Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-198 | Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.