Recombinant monoclonal antibody to CD22. Moxetumomab pasudotox is an anti-CD22 mouse monoclonal antibody designed for the treatment of cancer.
Figure 1 Pharmacokinetics of moxetumomab pasudotox.
(A) Peak plasma levels on cycle 1 are compared between dose 1 (day 1) and dose 3 (day 5). (B) Peak plasma levels and (C) areas under the curve (AUCs) are shown for cycle 1, day 5 at each of the dose levels.
Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.
Figure 2 Toxicity of moxetumomab pasudotox. Incidence of toxicity by cycle is shown by grade for all 114 cycles administered to 28 patients.
CPK, creatine phosphokinase; effu, effusion; GGT, γ-glutamyltransferase; HCL, hairy cell leukemia; H&N, head and neck; HGB, hemoglobin; HUS, hemolytic uremic syndrome; Hypo-MG, hypomagnesemia; SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase.
Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.
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