Anti-Human CD22 Recombinant Antibody (Moxetumomab Pasudotox) (CAT#: TAB-183-F(E))

Recombinant monoclonal antibody to CD22. Moxetumomab pasudotox is an anti-CD22 mouse monoclonal antibody designed for the treatment of cancer.

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Figure 1 Pharmacokinetics of moxetumomab pasudotox.

Figure 1 Pharmacokinetics of moxetumomab pasudotox.

(A) Peak plasma levels on cycle 1 are compared between dose 1 (day 1) and dose 3 (day 5). (B) Peak plasma levels and (C) areas under the curve (AUCs) are shown for cycle 1, day 5 at each of the dose levels.

Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.

Figure 2 Toxicity of moxetumomab pasudotox. Incidence of toxicity by cycle is shown by grade for all 114 cycles administered to 28 patients.

Figure 2 Toxicity of moxetumomab pasudotox. Incidence of toxicity by cycle is shown by grade for all 114 cycles administered to 28 patients.

CPK, creatine phosphokinase; effu, effusion; GGT, γ-glutamyltransferase; HCL, hairy cell leukemia; H&N, head and neck; HGB, hemoglobin; HUS, hemolytic uremic syndrome; Hypo-MG, hypomagnesemia; SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase.

Kreitman, R. J., Tallman, M. S., Robak, T., Coutre, S., Wilson, W. H., Stetler-Stevenson, M., ... & Pastan, I. (2012). Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology, 30(15), 1822.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • Fv - disulfide stabilized
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • FuncS, IF, Neut, ELISA, FC, IP, ICC
  • CAS
  • 1020748-57-5
  • Generic Name
  • Moxetumomab pasudotox
  • MW
  • 63.5 kDa
  • Related Disease
  • Hairy cell leukemia (HCL)

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Applications

  • Application Notes
  • The CD22 antibody has been reported in applications of PK, Cyt.

Target

  • Alternative Names
  • Moxetumomab pasudotox;1020748-57-5;CAT-8015;HA22;R490A;BL22 immunotoxin;CD22;CD22 molecule;CD22 antigen;B-cell receptor CD22;sialic acid binding Ig like lectin 2;SIGLEC 2;SIGLEC2;BL-CAM;T-cell surface antigen Leu-14;B-lymphocyte cell adhesion molecule;sia

Related Resources

  • Biosimilar Overview
Please refer to Moxetumomab Pasudotox Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Moxetumomab Pasudotox.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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