Anti-Human CD274 Recombinant Antibody (TAB-418CQ)

CAT#: TAB-418CQ

Recombinant monoclonal antibody to CD274. This antibody is a humanized IgG1 monoclonal antibody that specifically binds to PD-L1, preventing it from interacting with its receptors (PD-1 and B7.1) on T-cells and antigen-presenting cells.

Gene Expression
Figure 1 IF staining of human cell line U-251 MG Figure 2 IF staining of human cell line BJ Figure 3 IF staining of human cell line U-2 OS Figure 4 Colon Figure 5 Placenta Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • IgG1, κ
  • Specificity
  • Human CD274
  • Species Reactivity
  • Human
  • Applications
  • Used for immunoassay techniques such as: Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Immunofluorescence; Immunoprecipitation; Flow Cytometry
  • Conjugate
  • Unconjugated
  • Related Disease
  • Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial

Product Property

  • Purity
  • > 95% as determined by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • Programmed cell death 1 ligand 1; B7H1; B7-H1; PDL1; PD-L1; PDCD1L1; B7 homolog 1; B7 homologue 1
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Breast cancer biomarkers at key points during disease progression
Great Immunofluorescence Results
The antibody's effectiveness in IF allows detailed visualization of PD-L1 distribution at the cellular level. The exceptional clarity and low background ensure that our findings are sharp and unambiguous, greatly aiding in the interpretation of biological mechanisms.
Breast cancer biomarkers at key points during disease progression
Enhancing Cancer Biomarker Studies
Our studies focus on PD-L1 as a cancer biomarker. This antibody allows for comprehensive ELISA assays, enabling us to quantify expression levels with confidence and explore correlations with clinical outcomes, thereby driving impactful insights.

Q&As

  1. What are the recommended applications for this antibody?

    A: This recombinant monoclonal antibody is suitable for Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), and Flow Cytometry (FC). These applications enable detailed analyses of protein expression, function, and localization.

  2. How does this antibody contribute to flow cytometry?

    A: It allows precise detection and quantification of PD-L1 expression on human cells using flow cytometry. Its specificity affords low background noise and distinct separation between positive and negative populations.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-418CQ, RRID: AB_3111931)

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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