Anti-Human CD6 Recombinant Antibody (TAB-247)
CAT#: TAB-247
Recombinant monoclonal antibody to CD6. It is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. It, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_8_val_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_B_8_5_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_7_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000013725-CD6
❮
❯
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- WB, IF, IP, Neut, FuncS, ELISA, FC, Stim, Inhib, Activ
- Related Disease
- Psoriasis
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Applications
- Application Notes
- The CD6 antibody has been reported in applications of WB, IF, IP, Neut, FuncS, ELISA, FC, Stim, Inhib, Activ.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAB-247. Click the button above to contact us or submit your feedback about this product.
Very versatile antibody
This anti-CD6 antibody (TAB-247) is incredibly useful. The product data lists a wide range of applications, including WB, IF, IP, ELISA, and FC. I used it for immunofluorescence (IF) on human cells, and it performed well. The fact that it's a humanized IgG1-kappa derived from mouse is a key technical detail.
High purity, CHO-expressed
The>95% purity by SDS-PAGE was a major selling point for me. Knowing this recombinant antibody is expressed in CHO cells gives me assurance about the post-translational modifications and proper folding, which is important for functional studies. It was tested positive against the native human antigen, which is what my research required.
Q&As
-
What is the format of this Anti-CD6 antibody? Is it a standard mouse monoclonal?
A: This is an engineered recombinant antibody, not a standard mouse monoclonal. As the product data specifies, it is a Humanized antibody derived from a mouse source. Its isotype is IgG1 - kappa. This humanization process makes it a valuable tool for various research applications studying human T-cell biology, as it is designed to interact with the human CD6 antigen.
-
How pure is this antibody (TAB-247) and what applications can it be used for?
A: We ensure a high standard of quality for this reagent. The purity is specified as>95% by SDS-PAGE. It is a very versatile antibody that has been reported for a wide array of applications, including Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Neutralization (Neut), Functional Studies (FuncS), ELISA, and Flow Cytometry (FC), among others. It is expressed in CHO cells.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-247, RRID: AB_3111898)
Copy citation
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Biosimilar Overview
Please refer to Itolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Itolizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CD6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1416z | Mouse Anti-CD6 Recombinant Antibody (clone 23C11) | WB, FC, IHC, FuncS | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-325LC | Human Anti-CD6 Recombinant Antibody (TAB-325LC) | Cyt, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-325LC-S(P) | Human Anti-CD6 Recombinant Antibody; scFv Fragment (TAB-325LC-S(P)) | FC, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-325LC-F(E) | Human Anti-CD6 Recombinant Antibody; Fab Fragment (TAB-325LC-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1778MZ | Recombinant Mouse Anti-Human CD6 Antibody (clone NBF-2D20), APC-Conjugated | FC | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-399CQ | Mouse Anti-CD6 Recombinant Antibody (clone OX-124) | Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-400CQ | Human Anti-CD6 Recombinant Antibody (clone OX-126) | FC, IHC, IF, FuncS, Depletion, Block | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-401CQ | Rat Anti-Cd6 Recombinant Antibody (clone CBL311) | Block | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0573 | Hi-Affi™ Rabbit Anti-CD6 Recombinant Antibody (clone DS573AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0574 | Hi-Affi™ Rabbit Anti-CD6 Recombinant Antibody (clone DS574AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-247 | Afuco™ Anti-CD6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-247) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-023CQ | Mouse Anti-CD6 Recombinant Antibody (clone CBL-1300) | FC, FuncS, WB | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0043-YC | Human Anti-CD6 Recombinant Antibody (HPAB-N0043-YC) | ELISA, FC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0043-YC-S(P) | Human Anti-CD6 Recombinant Antibody; scFv Fragment (HPAB-N0043-YC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0043-YC-F(E) | Human Anti-CD6 Recombinant Antibody; Fab Fragment (HPAB-N0043-YC-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0009-YJ | Mouse Anti-CD6 Recombinant Antibody (clone IOR T1) | FuncS, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0009-YJ-S(P) | Mouse Anti-CD6 Recombinant Antibody (clone IOR T1); scFv Fragment | FuncS, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0009-YJ-F(E) | Mouse Anti-CD6 Recombinant Antibody (clone IOR T1); Fab Fragment | FuncS, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY63 | CytoStream™ Rat Anti-CD6 Recombinant Antibody (VS-0225-XY63) | FC | Rat IgG2a, lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY90 | Mouse Anti-CD6 (clone IOR-T1) scFv-Fc Chimera | ELISA | Mouse IgG2a, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC197 | Recombinant Anti-CD6 Vesicular Antibody, EV Displayed (VS-0425-YC197) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1206 | Anti-CD6 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC65 | SmartAb™ Recombinant Anti-CD6 pH-dependent Antibody (VS-0825-YC65) | WB, IF, IP, Neut, ELISA, FC | Human IgG1 kappa |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
-YJ5.png)
Application: WB, ELISA, FC, IHC, IP
Application: SPR, Inhib, FuncS
Application: ELISA, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
