Anti-Human CSF2 Therapeutic Antibody (Lenzilumab) (CAT#: TAB-H44)

Recombinant human antibody to Human CSF2

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Block

Figure 1 GM-CSF blockade helps control CART19 toxicities and may improve efficacy.

A) CART19 and lenzilumab treated CART19 and lenzilumab treated CART19 are equally effective in survival outcomes in a high tumor burden NALM6 relapse model compared to UTD (untransduced T cells) (7-8 mice per group, n=2) B-D) Lenzilumab & anti-mouse GM-CSF antibody controlled CRS induced weight loss, neutralized serum human GM-CSF, and reduced expression of serum mouse MCP-1 (monocyte chemoattractant protein-1) in a primary ALL xenograft CART19 CRS/NT model (3 mice per group, * p<0.05). E) Lenzilumab & anti-mouse GM-CSF antibody reduced brain inflammation as shown by MRI in a primary ALL XENOGRAFT CART19 CRS/NT model (3 mice per group, * p<0.05, ** p<0.01).F-G) CART19 + Lenzilumab & anti-mouse GM-CSF antibody treated mice showed reduced CD19+ brain leukemic burden and reduced percentage of brain macrophages in a primary ALL xenograft CART19 CRS/NT model (3 mice per group) H) CRISPR Cas9 K/O of GM-CSF reduces its expression via intracellular staining in CART19 and UTD with NALM6 stimulation.

Sterner, R. M., Sakemura, R., Yang, N., Cox, M. J., Khadka, R., Forsman, C. L.,... & Welch, B. M. (2019). GM-CSF Blockade during Chimeric Antigen Receptor T-Cell (CART) Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance CART Effector Functions. Biology of Blood and Marrow Transplantation, 25(3), S4.


Specifications

  • Host Species
  • human
  • Derivation
  • human
  • Type
  • IgG1 - kappa
  • Specificity
  • CSF2 (colony stimulating factor 2 (granulocyte-macrophage), granulocyte-macrophage colony stimulating factor, GM-CSF) [Homo sapiens]
  • Species Reactivity
  • Human
  • Applications
  • Neut, ELISA, IF, IP, FuncS, FC, IHC, Block
  • CAS
  • 1229575-09-0
  • Generic Name
  • lenzilumab
  • Related Disease
  • Inflammatory diseases

Applications

  • Application Notes
  • The CSF2 antibody has been reported in applications of Neut, ELISA, IF, IP, FuncS, FC, IHC, Block.

Target

  • Alternative Names
  • lenzilumab;1229575-09-0;KB003;CSF2;colony stimulating factor 2 (granulocyte-macrophage);granulocyte-macrophage colony-stimulating factor;GM CSF;GMCSF;granulocyte macrophage colony stimulating factor;molgramostin;sargramostim;CSF;colony-stimulating factor;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Resources

Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Lenzilumab.

See other products for "Lenzilumab"

Afuco™ Anti-CSF2 ADCC Therapeutic Antibody (Lenzilumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human CSF2.

See other products for "CSF2"


For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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