What applications is this antibody recommended for?

The Anti-DR5 Recombinant Antibody (TAB-180) is recommended for a wide range of applications including Functional Studies, IF, Neutralization, ELISA, FC, IP, ICC, WB, and SPR.

Is this antibody suitable for activating the receptor?

Yes, this antibody acts as an agonist. It binds to DR5 (TNFRSF10B) and can induce apoptosis signals, mimicking the activity of TRAIL. It is a powerful tool for studying death receptor signaling.

Anti-Human DR5 Recombinant Antibody (TAB-180)

CAT#: TAB-180

Recombinant monoclonal antibody to DR5. It is a human monoclonal antibody designed for the treatment of cancers.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

Neuropil
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg

Normal Tissue Figure 6 Lymph node

Non-germinal center cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B

❮

❯

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
IgG1 - lambda

Specificity
Tested positive against native human antigen.

Species Reactivity
Human

Applications
FuncS, IF, Neut, ELISA, FC, IP, ICC, WB, Activ, SPR

MW
143.1 kDa

Related Disease
Colorectal cancers

Product Property

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Applications

Application Notes
The TNFRSF10B antibody has been reported in applications of FuncS, IF, Neut, ELISA, FC, IP, ICC, WB, Activ, SPR.

Target

Alternative Names
TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic

Gene ID
8795

UniProt ID
O14763

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

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Breast cancer biomarkers at key points during disease progression

Versatile Functional Antibody

This antibody is a workhorse in our apoptosis research. We have used it for Functional Studies, Flow Cytometry, and Western Blot. It consistently activates the DR5 receptor in our assays, exactly as described. The human monoclonal format is ideal for our studies on colorectal cancer cell lines.

High Quality And Pure

The purity of this antibody is outstanding, over 97% by silver stain. We used it for SPR analysis to determine binding kinetics, and the data was very clean. It is rare to find such a well-characterized antibody that works across so many applications, including Immunoprecipitation and Immunofluorescence.

Q&As

What applications is this antibody recommended for?

A: The Anti-DR5 Recombinant Antibody (TAB-180) is recommended for a wide range of applications including Functional Studies, IF, Neutralization, ELISA, FC, IP, ICC, WB, and SPR.
Is this antibody suitable for activating the receptor?

A: Yes, this antibody acts as an agonist. It binds to DR5 (TNFRSF10B) and can induce apoptosis signals, mimicking the activity of TRAIL. It is a powerful tool for studying death receptor signaling.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-180, RRID: AB_3111853)

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Biosimilar Overview

Please refer to Drozitumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Drozitumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-180.pdf

MSDS

MSDS - TAB-180.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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